Literature DB >> 11141511

Integration of multidisciplinary sensory data: a pilot model of the human brain project approach.

P L Miller1, P Nadkarni, M Singer, L Marenco, M Hines, G Shepherd.   

Abstract

The paper provides an overview of neuroinformatics research at Yale University being performed as part of the national Human Brain Project. This research is exploring the integration of multidisciplinary sensory data, using the olfactory system as a model domain. The neuroinformatics activities fall into three main areas: 1) building databases and related tools that support experimental olfactory research at Yale and can also serve as resources for the field as a whole, 2) using computer models (molecular models and neuronal models) to help understand data being collected experimentally and to help guide further laboratory experiments, 3) performing basic neuroinformatics research to develop new informatics technologies, including a flexible data model (EAV/CR, entity-attribute-value with classes and relationships) designed to facilitate the integration of diverse heterogeneous data within a single unifying framework.

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Year:  2001        PMID: 11141511      PMCID: PMC134590          DOI: 10.1136/jamia.2001.0080034

Source DB:  PubMed          Journal:  J Am Med Inform Assoc        ISSN: 1067-5027            Impact factor:   4.497


  26 in total

1.  Neuronal database integration: the Senselab EAV data model.

Authors:  L Marenco; P Nadkarni; E Skoufos; G Shepherd; P Miller
Journal:  Proc AMIA Symp       Date:  1999

2.  Database tools for integrating and searching membrane property data correlated with neuronal morphology.

Authors:  J S Mirsky; P M Nadkarni; M D Healy; P L Miller; G M Shepherd
Journal:  J Neurosci Methods       Date:  1998-07-01       Impact factor: 2.390

3.  Combinatorial receptor codes for odors.

Authors:  B Malnic; J Hirono; T Sato; L B Buck
Journal:  Cell       Date:  1999-03-05       Impact factor: 41.582

4.  Olfactory Receptor Database: a database of the largest eukaryotic gene family.

Authors:  E Skoufos; M D Healy; M S Singer; P M Nadkarni; P L Miller; G M Shepherd
Journal:  Nucleic Acids Res       Date:  1999-01-01       Impact factor: 16.971

Review 5.  The Human Brain Project: neuroinformatics tools for integrating, searching and modeling multidisciplinary neuroscience data.

Authors:  G M Shepherd; J S Mirsky; M D Healy; M S Singer; E Skoufos; M S Hines; P M Nadkarni; P L Miller
Journal:  Trends Neurosci       Date:  1998-11       Impact factor: 13.837

6.  Identification of ligands for olfactory receptors by functional expression of a receptor library.

Authors:  D Krautwurst; K W Yau; R R Reed
Journal:  Cell       Date:  1998-12-23       Impact factor: 41.582

7.  Managing attribute--value clinical trials data using the ACT/DB client-server database system.

Authors:  P M Nadkarni; C Brandt; S Frawley; F G Sayward; R Einbinder; D Zelterman; L Schacter; P L Miller
Journal:  J Am Med Inform Assoc       Date:  1998 Mar-Apr       Impact factor: 4.497

8.  Functional expression of a mammalian odorant receptor.

Authors:  H Zhao; L Ivic; J M Otaki; M Hashimoto; K Mikoshiba; S Firestein
Journal:  Science       Date:  1998-01-09       Impact factor: 47.728

9.  Forward and backward propagation of dendritic impulses and their synaptic control in mitral cells.

Authors:  W R Chen; J Midtgaard; G M Shepherd
Journal:  Science       Date:  1997-10-17       Impact factor: 47.728

10.  Olfactory receptor database (ORDB): a resource for sharing and analyzing published and unpublished data.

Authors:  M D Healy; J E Smith; M S Singer; P M Nadkarni; E Skoufos; P L Miller; G M Shepherd
Journal:  Chem Senses       Date:  1997-06       Impact factor: 3.160

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  14 in total

1.  Human brain program research progress in bioinformatics/ neuroinformatics.

Authors:  S T Wong; S H Koslow
Journal:  J Am Med Inform Assoc       Date:  2001 Jan-Feb       Impact factor: 4.497

2.  Human Brain Program Research Progress in biomedical imaging/neuroscience, 2001.

Authors:  S T Wong; S H Koslow
Journal:  J Am Med Inform Assoc       Date:  2001 Sep-Oct       Impact factor: 4.497

3.  OpenSDE: Row modeling applied to generic structured data entry.

Authors:  Renske K Los; Astrid M van Ginneken; Marcel de Wilde; Johan van der Lei
Journal:  J Am Med Inform Assoc       Date:  2003-12-07       Impact factor: 4.497

4.  QIS: A framework for biomedical database federation.

Authors:  Luis Marenco; Tzuu-Yi Wang; Gordon Shepherd; Perry L Miller; Prakash Nadkarni
Journal:  J Am Med Inform Assoc       Date:  2004-08-06       Impact factor: 4.497

5.  Semi-automated population of an online database of neuronal models (ModelDB) with citation information, using PubMed for validation.

Authors:  Andrew P Davison; Thomas M Morse; Michele Migliore; Gordon M Shepherd; Michael L Hines
Journal:  Neuroinformatics       Date:  2004

6.  ModelDB: making models publicly accessible to support computational neuroscience.

Authors:  Michele Migliore; Thomas M Morse; Andrew P Davison; Luis Marenco; Gordon M Shepherd; Michael L Hines
Journal:  Neuroinformatics       Date:  2003

7.  BioMediator data integration: beyond genomics to neuroscience data.

Authors:  K Wang; P Tarczy-Hornoch; R Shaker; P Mork; J F Brinkley
Journal:  AMIA Annu Symp Proc       Date:  2005

8.  Dynamic tables: an architecture for managing evolving, heterogeneous biomedical data in relational database management systems.

Authors:  John Corwin; Avi Silberschatz; Perry L Miller; Luis Marenco
Journal:  J Am Med Inform Assoc       Date:  2006-10-26       Impact factor: 4.497

9.  SenseLab: new developments in disseminating neuroscience information.

Authors:  Chiquito J Crasto; Luis N Marenco; Nian Liu; Thomas M Morse; Kei-Hoi Cheung; Peter C Lai; Gautam Bahl; Peter Masiar; Hugo Y K Lam; Ernest Lim; Huajin Chen; Prakash Nadkarni; Michele Migliore; Perry L Miller; Gordon M Shepherd
Journal:  Brief Bioinform       Date:  2007-05-17       Impact factor: 11.622

10.  The NIF LinkOut broker: a web resource to facilitate federated data integration using NCBI identifiers.

Authors:  Luis Marenco; Giorgio A Ascoli; Maryann E Martone; Gordon M Shepherd; Perry L Miller
Journal:  Neuroinformatics       Date:  2008-10-31
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