Stochastic spreading of intracellular Ca(2+) release.

We study the spreading of calcium-induced calcium release with the stochastic DeYoung-Keizer-model of the inositol 1,4,5-trisphosphate receptor channel. The model shows a transition from isolated release events to steadily propagating waves with increasing IP3 concentration. A state--stochastic backfiring--was found in the regime of steady propagation. The model can be reduced by an adiabatic elimination of the partial differential equation for the Ca(2+) concentration to a lattice of stochastic channel clusters.