Literature DB >> 11055334

Analogues of SB-203207 as inhibitors of tRNA synthetases.

M G Banwell1, C F Crasto, C J Easton, A K Forrest, T Karoli, D R March, L Mensah, M R Nairn, P J O'Hanlon, M D Oldham, W Yue.   

Abstract

SB-203207 and 10 analogues have been prepared, by elaboration of altemicidin, and evaluated as inhibitors of isoleucyl, leucyl and valyl tRNA synthetases (IRS, LRS, and VRS, respectively). Substituting the isoleucine residue of SB-203207 with leucine and valine increased the potency of inhibition of LRS and VRS, respectively. The leucine derivative showed low level antibacterial activity, while several of the compounds inhibited IRS from Staphylococcus aureus WCUH29 more strongly than rat liver IRS.

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Year:  2000        PMID： 11055334     DOI： 10.1016/s0960-894x(00)00456-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

Review 1.  Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

Authors:  Julian Gregston Hurdle; Alexander John O'Neill; Ian Chopra
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

2.  IA, database of known ligands of aminoacyl-tRNA synthetases.

Authors:  Mieczyslaw Torchala; Marcin Hoffmann
Journal:  J Comput Aided Mol Des       Date:  2007-09-20       Impact factor: 3.686

3.  Search for inhibitors of aminoacyl-tRNA synthases by virtual click chemistry.

Authors:  Marcin Hoffmann; Mieczyslaw Torchala
Journal:  J Mol Model       Date:  2008-12-02       Impact factor: 1.810

Review 4.  Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.

Authors:  Christopher S Francklyn; Patrick Mullen
Journal:  J Biol Chem       Date:  2019-01-22       Impact factor: 5.157

5.  Crystal structures of isomeric 4-bromo-N-[(2-nitro-phen-yl)sulfon-yl]benzamide and 4-bromo-N-[(4-nitro-phen-yl)sulfon-yl]benzamide.

Authors:  S Naveen; A G Sudha; E Suresha; N K Lokanath; P A Suchetan; M Abdoh
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-02-03

Review 6.  Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis.

Authors:  Lena Barra; Takayoshi Awakawa; Ikuro Abe
Journal:  JACS Au       Date:  2022-08-17

7.  Crystal structures of three N-(aryl-sulfon-yl)-4-fluoro-benzamides.

Authors:  P A Suchetan; S Naveen; N K Lokanath; K S Srivishnu; G M Supriya; H N Lakshmikantha
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-03-31

8.  Crystal structures of N-(3-fluoro-benzo-yl)benzene-sulfonamide and N-(3-fluoro-benzo-yl)-4-methyl-benzene-sulfonamide.

Authors:  P A Suchetan; S Naveen; N K Lokanath; H N Lakshmikantha; K S Srivishnu; G M Supriya
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-03-02

9.  Synthesis, Molecular Structure, Metabolic Stability and QSAR Studies of a Novel Series of Anticancer N-Acylbenzenesulfonamides.

Authors:  Beata Żołnowska; Jarosław Sławiński; Mariusz Belka; Tomasz Bączek; Anna Kawiak; Jarosław Chojnacki; Aneta Pogorzelska; Krzysztof Szafrański
Journal:  Molecules       Date:  2015-10-21       Impact factor: 4.411
  9 in total

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