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Literature DB >> 17882381

IA, database of known ligands of aminoacyl-tRNA synthetases.

Abstract

The IA database contains 240 structures of known inhibitors of aminoacyl-tRNA synthetases. Structures can be downloaded in different file formats (mol, sdf, smile, png). The search engine offers possibility of searching for the ligands with a given functional group. Additionally, one can search for ligands that act on selected synthetases and from particular references. The data include information which synthetase a given ligand inhibits together with the inhibition constant (IC50) if known.

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Year: 2007 PMID： 17882381 DOI： 10.1007/s10822-007-9135-x

Source DB: PubMed Journal: J Comput Aided Mol Des ISSN： 0920-654X Impact factor: 3.686

29 in total

1. Analogues of SB-203207 as inhibitors of tRNA synthetases.

Authors: M G Banwell; C F Crasto; C J Easton; A K Forrest; T Karoli; D R March; L Mensah; M R Nairn; P J O'Hanlon; M D Oldham; W Yue
Journal: Bioorg Med Chem Lett Date: 2000-10-16 Impact factor: 2.823

2. Development of biologically active compounds by combining 3D QSAR and structure-based design methods.

Authors: Wolfgang Sippl
Journal: J Comput Aided Mol Des Date: 2002-11 Impact factor: 3.686

3. Comparative study of several algorithms for flexible ligand docking.

Authors: Badry D Bursulaya; Maxim Totrov; Ruben Abagyan; Charles L Brooks
Journal: J Comput Aided Mol Des Date: 2003-11 Impact factor: 3.686

Review 4. Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

Authors: Julian Gregston Hurdle; Alexander John O'Neill; Ian Chopra
Journal: Antimicrob Agents Chemother Date: 2005-12 Impact factor: 5.191

5. Assessing different classification methods for virtual screening.

Authors: Dariusz Plewczynski; Stéphane A H Spieser; Uwe Koch
Journal: J Chem Inf Model Date: 2006 May-Jun Impact factor: 4.956

Review 6. Aminoacyl tRNA synthetases as targets for new anti-infectives.

Authors: P Schimmel; J Tao; J Hill
Journal: FASEB J Date: 1998-12 Impact factor: 5.191

7. Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.

Authors: Su Yeon Kim; Eun-Jeong Yoon; Eung-Chil Choi; Sunghoon Kim; Taehee Kang; Farhana Samrin; Sadhna Puri; Jeewoo Lee
Journal: Bioorg Med Chem Date: 2006-07-18 Impact factor: 3.641

8. Efficacy of PLD-118, a novel inhibitor of candida isoleucyl-tRNA synthetase, against experimental oropharyngeal and esophageal candidiasis caused by fluconazole-resistant C. albicans.

Authors: Vidmantas Petraitis; Ruta Petraitiene; Amy M Kelaher; Alia A Sarafandi; Tin Sein; Diana Mickiene; John Bacher; Andreas H Groll; Thomas J Walsh
Journal: Antimicrob Agents Chemother Date: 2004-10 Impact factor: 5.191

Review 9. Sulfamates and their therapeutic potential.

Authors: Jean-Yves Winum; Andrea Scozzafava; Jean-Louis Montero; Claudiu T Supuran
Journal: Med Res Rev Date: 2005-03 Impact factor: 12.944

10. Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Authors: Richard L Jarvest; John M Berge; Pamela Brown; Catherine S V Houge-Frydrych; Peter J O'Hanlon; David J McNair; Andrew J Pope; Stephen Rittenhouse
Journal: Bioorg Med Chem Lett Date: 2003-04-07 Impact factor: 2.823

1 in total

1. Search for inhibitors of aminoacyl-tRNA synthases by virtual click chemistry.

Authors: Marcin Hoffmann; Mieczyslaw Torchala
Journal: J Mol Model Date: 2008-12-02 Impact factor: 1.810

1 in total