Literature DB >> 11037315

Genotyping for human whole-genome scans: past, present, and future.

J L Weber1, K W Broman.   

Abstract

Efficient and effective whole-genome 10-cM short tandem repeat polymorphism (STRP) scans are now available. Doubling or tripling STRP density to an average spacing of 3-5 cM is readily achievable. However, if typing costs for diallelic polymorphisms can be brought close to, or preferably less than, one-third those of STRPs, then diallelics may gradually supplement or supplant STRPs in whole-genome scans. The power of higher density genome scans for gene map ping by association and for many other research and clinical applications is great. It would be wise to continue investing heavily for many years in genotyping technology.

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Year:  2001        PMID： 11037315     DOI： 10.1016/s0065-2660(01)42016-5

Source DB:  PubMed          Journal:  Adv Genet        ISSN： 0065-2660            Impact factor:   1.944


  47 in total

Review 1.  Searching for the mountains of the moon: genome scans for atherosclerosis.

Authors:  Michael A Province
Journal:  Curr Atheroscler Rep       Date:  2002-05       Impact factor: 5.113

2.  A tale of two genotypes: consistency between two high-throughput genotyping centers.

Authors:  Daniel E Weeks; Yvette P Conley; Robert E Ferrell; Tammy S Mah; Michael B Gorin
Journal:  Genome Res       Date:  2002-03       Impact factor: 9.043

3.  The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time.

Authors:  Lev A Zhivotovsky; Peter A Underhill; Cengiz Cinnioğlu; Manfred Kayser; Bharti Morar; Toomas Kivisild; Rosaria Scozzari; Fulvio Cruciani; Giovanni Destro-Bisol; Gabriella Spedini; Geoffrey K Chambers; Rene J Herrera; Kiau Kiun Yong; David Gresham; Ivailo Tournev; Marcus W Feldman; Luba Kalaydjieva
Journal:  Am J Hum Genet       Date:  2003-12-19       Impact factor: 11.025

4.  A 3.9-centimorgan-resolution human single-nucleotide polymorphism linkage map and screening set.

Authors:  Tara C Matise; Ravi Sachidanandam; Andrew G Clark; Leonid Kruglyak; Ellen Wijsman; Jerzy Kakol; Steven Buyske; Buena Chui; Patrick Cohen; Claudia de Toma; Margaret Ehm; Stephen Glanowski; Chunsheng He; Jeremy Heil; Kyriacos Markianos; Ivy McMullen; Margaret A Pericak-Vance; Arkadiy Silbergleit; Lincoln Stein; Michael Wagner; Alexander F Wilson; Jeffrey D Winick; Emily S Winn-Deen; Carl T Yamashiro; Howard M Cann; Eric Lai; Arthur L Holden
Journal:  Am J Hum Genet       Date:  2003-07-03       Impact factor: 11.025

5.  A note on exact tests of Hardy-Weinberg equilibrium.

Authors:  Janis E Wigginton; David J Cutler; Goncalo R Abecasis
Journal:  Am J Hum Genet       Date:  2005-03-23       Impact factor: 11.025

6.  Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers.

Authors:  Gonçalo R Abecasis; Janis E Wigginton
Journal:  Am J Hum Genet       Date:  2005-09-20       Impact factor: 11.025

7.  Genetic characterization of a new set of recombinant inbred lines (LGXSM) formed from the inter-cross of SM/J and LG/J inbred mouse strains.

Authors:  Tomas Hrbek; Reinaldo Alves de Brito; B Wang; L Susan Pletscher; James M Cheverud
Journal:  Mamm Genome       Date:  2006-05       Impact factor: 2.957

8.  Evidence for extensive transmission distortion in the human genome.

Authors:  Sebastian Zöllner; Xiaoquan Wen; Neil A Hanchard; Mark A Herbert; Carole Ober; Jonathan K Pritchard
Journal:  Am J Hum Genet       Date:  2003-12-15       Impact factor: 11.025

9.  Confirmation of the ATP6B1 gene as responsible for distal renal tubular acidosis.

Authors:  Rainer Ruf; Cornelia Rensing; Rezan Topaloglu; Lisa Guay-Woodford; Cornelia Klein; Martin Vollmer; Edgar Otto; Frank Beekmann; Maria Haller; Alexander Wiedensohler; Ernst Leumann; Corinne Antignac; Gianfranco Rizzoni; Guido Filler; Matthias Brandis; James L Weber; Friedhelm Hildebrandt
Journal:  Pediatr Nephrol       Date:  2002-12-18       Impact factor: 3.714

10.  Genomewide linkage scan identifies a novel susceptibility locus for restless legs syndrome on chromosome 9p.

Authors:  Shenghan Chen; William G Ondo; Shaoqi Rao; Lin Li; Qiuyun Chen; Qing Wang
Journal:  Am J Hum Genet       Date:  2004-04-07       Impact factor: 11.025
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