Literature DB >> 11028076

Is Hydrogen Tunneling Involved in AcylCoA Desaturase Reactions? The Case of a Delta(9) Desaturase That Transforms (E)-11-Tetradecenoic Acid into (Z,E)-9,11-Tetradecadienoic Acid This work was supported by Comisión Asesora de Investigación Científica y Técnica (grant AGF 98-0844), Comissionat per a Universitats i Recerca from the Generalitat de Catalunya (grant 97SGR-0021) and SEDQ S.A. We thank Prof. Nigel S. Scrutton (University of Leicester, UK) and Dr. Francisco J. Sanchez-Baeza (IIQAB, Barcelona, Spain) for helpful discussions, Dr. Josefina Casas and Dr. Antonio Delgado for critically reading the manuscript, and Germán Lázaro for rearing the insects used in this study. J.L.A. thanks the Spanish Ministry of Education and Science for a Postdoctoral Reincorporation Contract.

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Year:  2000        PMID: 11028076     DOI: 10.1002/1521-3773(20000915)39:18<3279::aid-anie3279>3.0.co;2-g

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN: 1433-7851            Impact factor:   15.336


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  14 in total

1.  Linking protein structure and dynamics to catalysis: the role of hydrogen tunnelling.

Authors:  Judith P Klinman
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2006-08-29       Impact factor: 6.237

Review 2.  Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions.

Authors:  Jingzhi Pu; Jiali Gao; Donald G Truhlar
Journal:  Chem Rev       Date:  2006-08       Impact factor: 60.622

3.  Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors.

Authors:  Zachary D Nagel; Ming Dong; Brian J Bahnson; Judith P Klinman
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-13       Impact factor: 11.205

4.  Manganese catalysts for C-H activation: an experimental/theoretical study identifies the stereoelectronic factor that controls the switch between hydroxylation and desaturation pathways.

Authors:  Jonathan F Hull; David Balcells; Effiette L O Sauer; Christophe Raynaud; Gary W Brudvig; Robert H Crabtree; Odile Eisenstein
Journal:  J Am Chem Soc       Date:  2010-06-09       Impact factor: 15.419

5.  An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling.

Authors:  Judith P Klinman
Journal:  Chem Phys Lett       Date:  2009-03-26       Impact factor: 2.328

6.  Investigating inner-sphere reorganization via secondary kinetic isotope effects in the C-H cleavage reaction catalyzed by soybean lipoxygenase: tunneling in the substrate backbone as well as the transferred hydrogen.

Authors:  Matthew P Meyer; Judith P Klinman
Journal:  J Am Chem Soc       Date:  2010-12-30       Impact factor: 15.419

7.  Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

Authors:  Shenshen Hu; Adam R Offenbacher; Erin M Thompson; Christine L Gee; Jarett Wilcoxen; Cody A M Carr; Daniil M Prigozhin; Vanessa Yang; Tom Alber; R David Britt; James S Fraser; Judith P Klinman
Journal:  J Am Chem Soc       Date:  2019-01-15       Impact factor: 15.419

Review 8.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195

9.  Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB.

Authors:  Harriet L R Cooper; Girish Mishra; Xiongyi Huang; Marilla Pender-Cudlip; Rachel N Austin; John Shanklin; John T Groves
Journal:  J Am Chem Soc       Date:  2012-12-10       Impact factor: 15.419

10.  Synthesis of fluorinated analogs of myristic acid as potential inhibitors of Egyptian armyworm (Spodoptera littoralis) delta11 desaturase.

Authors:  José-Luis Abad; Gemma Villorbina; Gemma Fabriàs; Francisco Camps
Journal:  Lipids       Date:  2003-08       Impact factor: 1.880

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