Literature DB >> 11005849

Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness.

M A Ferguson1.   

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Year:  2000        PMID： 11005849      PMCID： PMC34041          DOI： 10.1073/pnas.97.20.10673

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  28 in total

1.  Leishmania mexicana mutants lacking glycosylphosphatidylinositol (GPI):protein transamidase provide insights into the biosynthesis and functions of GPI-anchored proteins.

Authors:  J D Hilley; J L Zawadzki; M J McConville; G H Coombs; J C Mottram
Journal:  Mol Biol Cell       Date:  2000-04       Impact factor: 4.138

2.  Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.

Authors:  T K Smith; D K Sharma; A Crossman; J S Brimacombe; M A Ferguson
Journal:  EMBO J       Date:  1999-11-01       Impact factor: 11.598

3.  Lipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania major.

Authors:  G F Späth; L Epstein; B Leader; S M Singer; H A Avila; S J Turco; S M Beverley
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

4.  Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.

Authors:  K Ohishi; N Inoue; Y Maeda; J Takeda; H Riezman; T Kinoshita
Journal:  Mol Biol Cell       Date:  2000-05       Impact factor: 4.138

5.  Lipophosphoglycan is not required for infection of macrophages or mice by Leishmania mexicana.

Authors:  T Ilg
Journal:  EMBO J       Date:  2000-05-02       Impact factor: 11.598

Review 6.  The transferrin receptor of Trypanosoma brucei.

Authors:  D Steverding
Journal:  Parasitol Int       Date:  2000-01       Impact factor: 2.230

7.  Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei.

Authors:  K Nagamune; T Nozaki; Y Maeda; K Ohishi; T Fukuma; T Hara; R T Schwarz; C Sutterlin; R Brun; H Riezman; T Kinoshita
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-12       Impact factor: 11.205

8.  Cell-free synthesis of glycosyl-phosphatidylinositol precursors for the glycolipid membrane anchor of Trypanosoma brucei variant surface glycoproteins. Structural characterization of putative biosynthetic intermediates.

Authors:  A K Menon; R T Schwarz; S Mayor; G A Cross
Journal:  J Biol Chem       Date:  1990-06-05       Impact factor: 5.157

9.  Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2.

Authors:  R Watanabe; Y Murakami; M D Marmor; N Inoue; Y Maeda; J Hino; K Kangawa; M Julius; T Kinoshita
Journal:  EMBO J       Date:  2000-08-15       Impact factor: 11.598

10.  Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors.

Authors:  Y S Morita; K S Paul; P T Englund
Journal:  Science       Date:  2000-04-07       Impact factor: 47.728
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  19 in total

1.  Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers.

Authors:  Mihaela Lorger; Markus Engstler; Matthias Homann; H Ulrich Göringer
Journal:  Eukaryot Cell       Date:  2003-02

2.  Specificity of GlcNAc-PI de-N-acetylase of GPI biosynthesis and synthesis of parasite-specific suicide substrate inhibitors.

Authors:  T K Smith; A Crossman; C N Borissow; M J Paterson; A Dix; J S Brimacombe; M A Ferguson
Journal:  EMBO J       Date:  2001-07-02       Impact factor: 11.598

Review 3.  Subcellular targeting strategies for drug design and delivery.

Authors:  Lawrence Rajendran; Hans-Joachim Knölker; Kai Simons
Journal:  Nat Rev Drug Discov       Date:  2010-01       Impact factor: 84.694

Review 4.  Lipid metabolism in Trypanosoma brucei.

Authors:  Terry K Smith; Peter Bütikofer
Journal:  Mol Biochem Parasitol       Date:  2010-04-09       Impact factor: 1.759

5.  PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8.

Authors:  K Ohishi; N Inoue; T Kinoshita
Journal:  EMBO J       Date:  2001-08-01       Impact factor: 11.598

6.  Characterization of the inositol phosphorylceramide synthase activity from Trypanosoma cruzi.

Authors:  Juliana M Figueiredo; Wagner B Dias; Lucia Mendonça-Previato; José O Previato; Norton Heise
Journal:  Biochem J       Date:  2005-04-15       Impact factor: 3.857

7.  PIG-W is critical for inositol acylation but not for flipping of glycosylphosphatidylinositol-anchor.

Authors:  Yoshiko Murakami; Uamporn Siripanyapinyo; Yeongjin Hong; Ji Young Kang; Sonoko Ishihara; Hideki Nakakuma; Yusuke Maeda; Taroh Kinoshita
Journal:  Mol Biol Cell       Date:  2003-06-13       Impact factor: 4.138

8.  First small molecular inhibitors of T. brucei dolicholphosphate mannose synthase (DPMS), a validated drug target in African sleeping sickness.

Authors:  Terry K Smith; Benjamin L Young; Helen Denton; David L Hughes; Gerd K Wagner
Journal:  Bioorg Med Chem Lett       Date:  2009-01-30       Impact factor: 2.823

9.  Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway.

Authors:  Aita Signorell; Monika Rauch; Jennifer Jelk; Michael A J Ferguson; Peter Bütikofer
Journal:  J Biol Chem       Date:  2008-06-28       Impact factor: 5.157

10.  Sugar nucleotide pools of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major.

Authors:  Daniel C Turnock; Michael A J Ferguson
Journal:  Eukaryot Cell       Date:  2007-06-08
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