Literature DB >> 11227758

The transferrin receptor of Trypanosoma brucei.

D Steverding1.   

Abstract

Bloodstream forms of Trypanosoma brucei, the causative agent of sleeping sickness in humans, require transferrin for growth. Uptake of host transferrin is mediated by a heterodimeric glycosylphosphatidylinositol-anchored receptor. The trypanosomal transferrin receptor is homologous to the N-terminal domain of the variant surface glycoprotein (VSG) and bears no structural similarity with the human transferrin receptor. In this review, the structure, biochemical properties and function of the transferrin receptor of T. brucei are summarized and compared to the transferrin receptor of mammalian cells.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11227758     DOI： 10.1016/s1383-5769(99)00018-5

Source DB:  PubMed          Journal:  Parasitol Int        ISSN： 1383-5769            Impact factor:   2.230


  28 in total

1.  Glycosylphosphatidylinositol biosynthesis validated as a drug target for African sleeping sickness.

Authors:  M A Ferguson
Journal:  Proc Natl Acad Sci U S A       Date:  2000-09-26       Impact factor: 11.205

2.  Three-dimensional cellular architecture of the flagellar pocket and associated cytoskeleton in trypanosomes revealed by electron microscope tomography.

Authors:  Sylvain Lacomble; Sue Vaughan; Catarina Gadelha; Mary K Morphew; Michael K Shaw; J Richard McIntosh; Keith Gull
Journal:  J Cell Sci       Date:  2009-03-19       Impact factor: 5.285

3.  Immunobiology of African trypanosomes: need of alternative interventions.

Authors:  Toya Nath Baral
Journal:  J Biomed Biotechnol       Date:  2010-02-23

4.  The endocytic activity of the flagellar pocket in Trypanosoma brucei is regulated by an adjacent phosphatidylinositol phosphate kinase.

Authors:  Lars Demmel; Katy Schmidt; Louise Lucast; Katharina Havlicek; Armin Zankel; Tina Koestler; Viktoria Reithofer; Pietro de Camilli; Graham Warren
Journal:  J Cell Sci       Date:  2014-03-17       Impact factor: 5.285

5.  Transferrin regulates mRNA levels of a gene involved in iron utilization in Entamoeba histolytica.

Authors:  Cristhian Sánchez-Cruz; Mavil López-Casamichana; Areli Cruz-Castañeda; José de Jesús Olivares-Trejo
Journal:  Mol Biol Rep       Date:  2011-09-27       Impact factor: 2.316

6.  Galactose metabolism is essential for the African sleeping sickness parasite Trypanosoma brucei.

Authors:  Janine R Roper; Maria Lucia S Guther; Kenneth G Milne; Michael A J Ferguson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-30       Impact factor: 11.205

7.  Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome.

Authors:  Paul J Guyett; Shuangluo Xia; David C Swinney; Michael P Pollastri; Kojo Mensa-Wilmot
Journal:  ACS Infect Dis       Date:  2016-06-16       Impact factor: 5.084

8.  New chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugs.

Authors:  Ranjan Behera; Sarah M Thomas; Kojo Mensa-Wilmot
Journal:  Antimicrob Agents Chemother       Date:  2014-01-27       Impact factor: 5.191

9.  Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis.

Authors:  Gautam Patel; Caitlin E Karver; Ranjan Behera; Paul J Guyett; Catherine Sullenberger; Peter Edwards; Norma E Roncal; Kojo Mensa-Wilmot; Michael P Pollastri
Journal:  J Med Chem       Date:  2013-05-03       Impact factor: 7.446

Review 10.  Pumping iron: a potential target for novel therapeutics against schistosomes.

Authors:  Amber Glanfield; Donald P McManus; Greg J Anderson; Malcolm K Jones
Journal:  Trends Parasitol       Date:  2007-10-24
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.