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Literature DB >> 20043027

Subcellular targeting strategies for drug design and delivery.

Lawrence Rajendran¹, Hans-Joachim Knölker, Kai Simons.

Abstract

Many drug targets are localized to particular subcellular compartments, yet current drug design strategies are focused on bioavailability and tissue targeting and rarely address drug delivery to specific intracellular compartments. Insights into how the cell traffics its constituents to these different cellular locations could improve drug design. In this Review, we explore the fundamentals of membrane trafficking and subcellular organization, as well as strategies used by pathogens to appropriate these mechanisms and the implications for drug design and delivery.

Mesh：

Year: 2010 PMID： 20043027 DOI： 10.1038/nrd2897

Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694

172 in total

Review 1. Rab proteins as membrane organizers.

Authors: M Zerial; H McBride
Journal: Nat Rev Mol Cell Biol Date: 2001-02 Impact factor: 94.444

2. Endosomes as a route for drug delivery in the real world.

Authors: David Sheff
Journal: Adv Drug Deliv Rev Date: 2004-04-23 Impact factor: 15.470

Review 3. Signaling on the endocytic pathway.

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Journal: Curr Opin Cell Biol Date: 2007-07-26 Impact factor: 8.382

4. Opioid receptor types selectively cointernalize with G protein-coupled receptor kinases 2 and 3.

Authors: Rüdiger Schulz; Andrea Wehmeyer; Karin Schulz
Journal: J Pharmacol Exp Ther Date: 2002-02 Impact factor: 4.030

5. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development.

Authors: Annette Schenck; Livia Goto-Silva; Claudio Collinet; Muriel Rhinn; Angelika Giner; Bianca Habermann; Michael Brand; Marino Zerial
Journal: Cell Date: 2008-05-02 Impact factor: 41.582

6. Endosome-to-cytosol transport of viral nucleocapsids.

Authors: Isabelle Le Blanc; Pierre-Philippe Luyet; Véronique Pons; Charles Ferguson; Neil Emans; Anne Petiot; Nathalie Mayran; Nicolas Demaurex; Julien Fauré; Rémy Sadoul; Robert G Parton; J Gruenberg
Journal: Nat Cell Biol Date: 2005-06-12 Impact factor: 28.824

7. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes.

Authors: Kosuke Miyauchi; Yuri Kim; Olga Latinovic; Vladimir Morozov; Gregory B Melikyan
Journal: Cell Date: 2009-05-01 Impact factor: 41.582

8. Transferrin directed delivery of adriamycin to human cells.

Authors: M Singh; H Atwal; R Micetich
Journal: Anticancer Res Date: 1998 May-Jun Impact factor: 2.480

9. Silencing by small RNAs is linked to endosomal trafficking.

Authors: Young Sik Lee; Sigal Pressman; Arlise P Andress; Kevin Kim; Jamie L White; Justin J Cassidy; Xin Li; Kim Lubell; Do Hwan Lim; Ik Sang Cho; Kenji Nakahara; Jonathan B Preall; Priya Bellare; Erik J Sontheimer; Richard W Carthew
Journal: Nat Cell Biol Date: 2009-08-16 Impact factor: 28.824

Review 10. Interfering with disease: a progress report on siRNA-based therapeutics.

Authors: Antonin de Fougerolles; Hans-Peter Vornlocher; John Maraganore; Judy Lieberman
Journal: Nat Rev Drug Discov Date: 2007-06 Impact factor: 84.694

178 in total

1. Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].

Authors: Hui Ding; Satoshi Inoue; Alexander V Ljubimov; Rameshwar Patil; Jose Portilla-Arias; Jinwei Hu; Bindu Konda; Kolja A Wawrowsky; Manabu Fujita; Natalya Karabalin; Takako Sasaki; Keith L Black; Eggehard Holler; Julia Y Ljubimova
Journal: Proc Natl Acad Sci U S A Date: 2010-10-04 Impact factor: 11.205

2. Multifunctional spider silk polymers for gene delivery to human mesenchymal stem cells.

Authors: Olena S Tokareva; Dean L Glettig; Rosalyn D Abbott; David L Kaplan
Journal: J Biomed Mater Res B Appl Biomater Date: 2014-11-17 Impact factor: 3.368

Review 3. Treating metastatic cancer with nanotechnology.

Authors: Avi Schroeder; Daniel A Heller; Monte M Winslow; James E Dahlman; George W Pratt; Robert Langer; Tyler Jacks; Daniel G Anderson
Journal: Nat Rev Cancer Date: 2011-12-23 Impact factor: 60.716

Review 4. Tumor-targeted drug delivery with aptamers.

Authors: Y Zhang; H Hong; W Cai
Journal: Curr Med Chem Date: 2011 Impact factor: 4.530

5. Chemical modification of capuramycins to enhance antibacterial activity.

Authors: Elena Bogatcheva; Tia Dubuisson; Marina Protopopova; Leo Einck; Carol A Nacy; Venkata M Reddy
Journal: J Antimicrob Chemother Date: 2010-12-23 Impact factor: 5.790

Review 6. Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology.

Authors: Lara Milane; Shanthi Ganesh; Shruti Shah; Zhen-Feng Duan; Mansoor Amiji
Journal: J Control Release Date: 2011-04-08 Impact factor: 9.776

7. Topical delivery of siRNA into skin using SPACE-peptide carriers.

Authors: Ming Chen; Michael Zakrewsky; Vivek Gupta; Aaron C Anselmo; Deborah H Slee; John A Muraski; Samir Mitragotri
Journal: J Control Release Date: 2014-01-13 Impact factor: 9.776

8. Epidermal growth factor receptor targeted nuclear delivery and high-resolution whole cell X-ray imaging of Fe3O4@TiO2 nanoparticles in cancer cells.

Authors: Ye Yuan; Si Chen; Tatjana Paunesku; Sophie Charlotte Gleber; William C Liu; Caroline B Doty; Rachel Mak; Junjing Deng; Qiaoling Jin; Barry Lai; Keith Brister; Claus Flachenecker; Chris Jacobsen; Stefan Vogt; Gayle E Woloschak
Journal: ACS Nano Date: 2013-11-27 Impact factor: 15.881

Review 9. Synthetic nanoelectronic probes for biological cells and tissues.

Authors: Bozhi Tian; Charles M Lieber
Journal: Annu Rev Anal Chem (Palo Alto Calif) Date: 2013-02-28 Impact factor: 10.745

10. Endocytic uptake pathways utilized by CPMV nanoparticles.

Authors: Emily M Plummer; Marianne Manchester
Journal: Mol Pharm Date: 2012-09-20 Impact factor: 4.939