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13 in total

1. Why randomized controlled trials fail but needn't: 1. Failure to gain "coal-face" commitment and to use the uncertainty principle.

Authors: D L Sackett
Journal: CMAJ Date: 2000-05-02 Impact factor: 8.262

Review 2. Why should we include women and minorities in randomized controlled trials?

Authors: C Weijer; R A Crouch
Journal: J Clin Ethics Date: 1999

3. Placebo-controlled trials in schizophrenia: are they ethical? Are they necessary?

Authors: C Weijer
Journal: Schizophr Res Date: 1999-02-15 Impact factor: 4.939

4. Of mice but not men. Problems of the randomized clinical trial.

Authors: S Hellman; D S Hellman
Journal: N Engl J Med Date: 1991-05-30 Impact factor: 91.245

5. Trials: the next 50 years. Large scale randomised evidence of moderate benefits.

Authors: R Peto; C Baigent
Journal: BMJ Date: 1998-10-31

Review 6. Using anecdotal information in evidence-based health care: heresy or necessity?

Authors: M W Enkin; A R Jadad
Journal: Ann Oncol Date: 1998-09 Impact factor: 32.976

7. A study in contrasts: eligibility criteria in a twenty-year sample of NSABP and POG clinical trials. National Surgical Adjuvant Breast and Bowel Program. Pediatric Oncology Group.

Authors: A Fuks; C Weijer; B Freedman; S Shapiro; M Skrutkowska; A Riaz
Journal: J Clin Epidemiol Date: 1998-02 Impact factor: 6.437

8. Equipoise and the ethics of clinical research.

Authors: B Freedman
Journal: N Engl J Med Date: 1987-07-16 Impact factor: 91.245

9. Explanatory and pragmatic attitudes in therapeutical trials.

Authors: D Schwartz; J Lellouch
Journal: J Chronic Dis Date: 1967-08

10. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. I. Introduction and design.

Authors: R Peto; M C Pike; P Armitage; N E Breslow; D R Cox; S V Howard; N Mantel; K McPherson; J Peto; P G Smith
Journal: Br J Cancer Date: 1976-12 Impact factor: 7.640

38 in total

1. Uncertainty about clinical equipoise. Clinical equipoise and the uncertainty principles both require further scrutiny.

Authors: F Gifford
Journal: BMJ Date: 2001-03-31

2. Why Sackett's analysis of randomized controlled trials fails, but needn't.

Authors: S H Shapiro; K C Glass
Journal: CMAJ Date: 2000-10-03 Impact factor: 8.262

3. Ethical issues in surgical research.

Authors: Patrick J McDonald; Abhaya V Kulkarni; Forough Farrokhyar; Mohit Bhandari
Journal: Can J Surg Date: 2010-04 Impact factor: 2.089

4. Extending clinical equipoise to phase 1 trials involving patients: unresolved problems.

Authors: James A Anderson; Jonathan Kimmelman
Journal: Kennedy Inst Ethics J Date: 2010-03

Review 5. Should desperate volunteers be included in randomised controlled trials?

Authors: P Allmark; S Mason
Journal: J Med Ethics Date: 2006-09 Impact factor: 2.903

6. Could a randomised trial answer the controversy relating to elective caesarean section? National survey of consultant obstetricians and heads of midwifery.

Authors: Tina Lavender; Carol Kingdon; Anna Hart; Gill Gyte; Mark Gabbay; James P Neilson
Journal: BMJ Date: 2005-08-22

For and against: clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial.