Literature DB >> 10813014

Why randomized controlled trials fail but needn't: 1. Failure to gain "coal-face" commitment and to use the uncertainty principle.

D L Sackett1.   

Abstract

Mesh：

Year:  2000        PMID： 10813014      PMCID： PMC1232415     

Source DB:  PubMed          Journal:  CMAJ        ISSN： 0820-3946            Impact factor:   8.262


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  6 in total

1.  Of mice but not men. Problems of the randomized clinical trial.

Authors:  S Hellman; D S Hellman
Journal:  N Engl J Med       Date:  1991-05-30       Impact factor: 91.245

2.  Trials: the next 50 years. Large scale randomised evidence of moderate benefits.

Authors:  R Peto; C Baigent
Journal:  BMJ       Date:  1998-10-31

3.  Equipoise and the ethics of segmental liver transplantation.

Authors:  P A Singer; J D Lantos; P F Whitington; C E Broelsch; M Siegler
Journal:  Clin Res       Date:  1988-10

4.  Equipoise and the ethics of clinical research.

Authors:  B Freedman
Journal:  N Engl J Med       Date:  1987-07-16       Impact factor: 91.245

5.  Subverting randomization in controlled trials.

Authors:  K F Schulz
Journal:  JAMA       Date:  1995-11-08       Impact factor: 56.272

6.  Equipoise and the ethics of randomization.

Authors:  R J Lilford; J Jackson
Journal:  J R Soc Med       Date:  1995-10       Impact factor: 5.344
  6 in total
  16 in total

1.  Why Sackett's analysis of randomized controlled trials fails, but needn't.

Authors:  S H Shapiro; K C Glass
Journal:  CMAJ       Date:  2000-10-03       Impact factor: 8.262

2.  Why randomized controlled trials fail but needn't: 2. Failure to employ physiological statistics, or the only formula a clinician-trialist is ever likely to need (or understand!).

Authors:  D L Sackett
Journal:  CMAJ       Date:  2001-10-30       Impact factor: 8.262

3.  Uncertainty about clinical equipoise.

Authors:  F Rolleston
Journal:  CMAJ       Date:  2001-06-26       Impact factor: 8.262

4.  For and against: clinical equipoise and not the uncertainty principle is the moral underpinning of the randomised controlled trial.

Authors:  C Weijer; S H Shapiro; K Cranley Glass
Journal:  BMJ       Date:  2000-09-23

Review 5.  Plea of the defence-critical comments on the interpretation of EVA3S, SPACE and ICSS.

Authors:  Jens Fiehler; Søren Jacob Bakke; Andrew Clifton; Emmanuel Houdart; Olav Jansen; Daniel Rüfenacht; Michael Söderman; Christophe Cognard
Journal:  Neuroradiology       Date:  2010-05-04       Impact factor: 2.804

6.  Uncertainty and the ethics of clinical trials.

Authors:  Sven Ove Hansson
Journal:  Theor Med Bioeth       Date:  2006

7.  [Ethical and empirical limitations of randomized controlled trials].

Authors:  Franz Porzsolt; Hartmut Kliemt
Journal:  Med Klin (Munich)       Date:  2008-12-20

8.  Clinical trials in crisis: Four simple methodologic fixes.

Authors:  Andrew J Vickers
Journal:  Clin Trials       Date:  2014-10-01       Impact factor: 2.486

9.  Recent controversies on comparative effectiveness research investigations: Challenges, opportunities, and pitfalls.

Authors:  Haresh Kirpalani; William E Truog; Carl T D'Angio; Michael Cotten
Journal:  Semin Perinatol       Date:  2016-08-08       Impact factor: 3.300

10.  Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality.

Authors:  Dean T Eurich; Ross T Tsuyuki; Sumit R Majumdar; Finlay A McAlister; Richard Lewanczuk; Marcelo C Shibata; Jeffrey A Johnson
Journal:  Trials       Date:  2009-02-09       Impact factor: 2.279
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