| Literature DB >> 10984264 |
Abstract
Insulin-like growth factor I (IGF-I) stimulates osteoblastic cells in culture to proliferate and to synthesize bone matrix proteins. However, local IGF-I action is modulated by a family of IGF-binding proteins (IGFBPs) that, in turn, are modified by specific IGFBP proteases. All these components of the IGF-I regulatory system are present and operative in bone cells in vitro.Entities:
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Year: 2000 PMID: 10984264 DOI: 10.1016/s1096-6374(00)80020-9
Source DB: PubMed Journal: Growth Horm IGF Res ISSN: 1096-6374 Impact factor: 2.372