OBJECTIVES: Bone regeneration is often needed prior to dental implant treatment due to the lack of adequate quantity and quality after infectious diseases. The greatest regenerative power was obtained with autologous tissue, primarily the bone alive, taken from the same site or adjacent sites, up to the use centrifugation of blood with the selection of the parts with the greatest potential regenerative. In fact, various techniques and technologies were chronologically successive to cope with an ever better preparation of these concentrates of blood. Our aim is to review these advances and discuss the ways in which platelet concentrates may provide such unexpected beneficial therapeutic effects. METHODS: The research has been carried out in the MEDLINE and Cochrane Central Register of Controlled Trials database by choosing keywords as "platelet rich plasma", "platelet rich fibrin", "platelet growth factors", and "bone regeneration" and "dentistry". RESULTS: Autologous platelet rich plasma is a safe and low cost procedure to deliver growth factors for bone and soft tissue healing. CONCLUSION: The great heterogeneity of clinical outcomes can be explained by the different PRP products with qualitative and quantitative difference among substance.
OBJECTIVES: Bone regeneration is often needed prior to dental implant treatment due to the lack of adequate quantity and quality after infectious diseases. The greatest regenerative power was obtained with autologous tissue, primarily the bone alive, taken from the same site or adjacent sites, up to the use centrifugation of blood with the selection of the parts with the greatest potential regenerative. In fact, various techniques and technologies were chronologically successive to cope with an ever better preparation of these concentrates of blood. Our aim is to review these advances and discuss the ways in which platelet concentrates may provide such unexpected beneficial therapeutic effects. METHODS: The research has been carried out in the MEDLINE and Cochrane Central Register of Controlled Trials database by choosing keywords as "platelet rich plasma", "platelet rich fibrin", "platelet growth factors", and "bone regeneration" and "dentistry". RESULTS: Autologous platelet rich plasma is a safe and low cost procedure to deliver growth factors for bone and soft tissue healing. CONCLUSION: The great heterogeneity of clinical outcomes can be explained by the different PRP products with qualitative and quantitative difference among substance.
Authors: Maria Vittoria Diamanti; Barbara Del Curto; Alberto Barlattani; Patrizio Bollero; Liliana Ottria; Mariapia Pedeferri Journal: J Appl Biomater Biomech Date: 2009 Jan-Apr
Authors: David M Dohan Ehrenfest; Isabel Andia; Matthias A Zumstein; Chang-Qing Zhang; Nelson R Pinto; Tomasz Bielecki Journal: Muscles Ligaments Tendons J Date: 2014-05-08
Authors: Xia Zhao; Daniel A Hu; Di Wu; Fang He; Hao Wang; Linjuan Huang; Deyao Shi; Qing Liu; Na Ni; Mikhail Pakvasa; Yongtao Zhang; Kai Fu; Kevin H Qin; Alexander J Li; Ofir Hagag; Eric J Wang; Maya Sabharwal; William Wagstaff; Russell R Reid; Michael J Lee; Jennifer Moriatis Wolf; Mostafa El Dafrawy; Kelly Hynes; Jason Strelzow; Sherwin H Ho; Tong-Chuan He; Aravind Athiviraham Journal: Front Bioeng Biotechnol Date: 2021-03-25