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Literature DB >> 19249350

PTH and PTHrP signaling in osteoblasts.

Abstract

The striking clinical benefit of PTH in osteoporosis began a new era of skeletal anabolic agents. Several studies have been performed, new studies are emerging out and yet controversies remain on PTH anabolic action in bone. This review focuses on the molecular aspects of PTH and PTHrP signaling in light of old players and recent advances in understanding the control of osteoblast proliferation, differentiation and function.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19249350 PMCID： PMC2723940 DOI： 10.1016/j.cellsig.2009.02.012

Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315

226 in total

1. Evidence that anabolic effects of PTH on bone require IGF-I in growing mice.

Authors: N Miyakoshi; Y Kasukawa; T A Linkhart; D J Baylink; S Mohan
Journal: Endocrinology Date: 2001-10 Impact factor: 4.736

2. The Wnt co-receptor LRP5 is essential for skeletal mechanotransduction but not for the anabolic bone response to parathyroid hormone treatment.

Authors: Kimihiko Sawakami; Alexander G Robling; Minrong Ai; Nathaniel D Pitner; Dawei Liu; Stuart J Warden; Jiliang Li; Peter Maye; David W Rowe; Randall L Duncan; Matthew L Warman; Charles H Turner
Journal: J Biol Chem Date: 2006-06-20 Impact factor: 5.157

3. Overexpression of the transcriptional factor Runx2 in osteoblasts abolishes the anabolic effect of parathyroid hormone in vivo.

Authors: Didier Merciris; Caroline Marty; Corinne Collet; Marie-Christine de Vernejoul; Valerie Geoffroy
Journal: Am J Pathol Date: 2007-05 Impact factor: 4.307

4. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide.

Authors: H Jüppner; A B Abou-Samra; M Freeman; X F Kong; E Schipani; J Richards; L F Kolakowski; J Hock; J T Potts; H M Kronenberg
Journal: Science Date: 1991-11-15 Impact factor: 47.728

5. Parathyroid hormone inhibits collagen synthesis at both ribonucleic acid and protein levels in rat osteogenic sarcoma cells.

Authors: N C Partridge; C A Dickson; K Kopp; S L Teitelbaum; E C Crouch; A J Kahn
Journal: Mol Endocrinol Date: 1989-02

6. Cloning and regulation of rat tissue inhibitor of metalloproteinases-2 in osteoblastic cells.

Authors: T F Cook; J S Burke; K D Bergman; C O Quinn; J J Jeffrey; N C Partridge
Journal: Arch Biochem Biophys Date: 1994-06 Impact factor: 4.013

7. Impact of the mitogen-activated protein kinase pathway on parathyroid hormone-related protein actions in osteoblasts.

Authors: Chen Chen; Amy J Koh; Nabanita S Datta; Jian Zhang; Evan T Keller; Guozhi Xiao; Renny T Franceschi; Nisha J D'Silva; Laurie K McCauley
Journal: J Biol Chem Date: 2004-05-05 Impact factor: 5.157

8. Parathyroid hormone induces c-fos and c-jun messenger RNA in rat osteoblastic cells.

Authors: J C Clohisy; D K Scott; K D Brakenhoff; C O Quinn; N C Partridge
Journal: Mol Endocrinol Date: 1992-11

9. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Authors: A B Abou-Samra; H Jüppner; T Force; M W Freeman; X F Kong; E Schipani; P Urena; J Richards; J V Bonventre; J T Potts
Journal: Proc Natl Acad Sci U S A Date: 1992-04-01 Impact factor: 11.205

10. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism.

Authors: Teresita Bellido; A Afshan Ali; Lilian I Plotkin; Qiang Fu; Igor Gubrij; Paula K Roberson; Robert S Weinstein; Charles A O'Brien; Stavros C Manolagas; Robert L Jilka
Journal: J Biol Chem Date: 2003-10-01 Impact factor: 5.157

107 in total

1. Role of PTH1R internalization in osteoblasts and bone mass using a phosphorylation-deficient knock-in mouse model.

Authors: Nabanita S Datta; Tareq A Samra; Chandrika D Mahalingam; Tanuka Datta; Abdul B Abou-Samra
Journal: J Endocrinol Date: 2010-10-07 Impact factor: 4.286

2. A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo.

Authors: Shannon H Carroll; Nathan A Wigner; Nitin Kulkarni; Hillary Johnston-Cox; Louis C Gerstenfeld; Katya Ravid
Journal: J Biol Chem Date: 2012-03-08 Impact factor: 5.157

Review 3. Osteoblastogenesis regulation signals in bone remodeling.

Authors: C Zuo; Y Huang; R Bajis; M Sahih; Y-P Li; K Dai; X Zhang
Journal: Osteoporos Int Date: 2012-06 Impact factor: 4.507

Review 4. Catabolic and anabolic actions of parathyroid hormone on the skeleton.

Authors: B C Silva; A G Costa; N E Cusano; S Kousteni; J P Bilezikian
Journal: J Endocrinol Invest Date: 2011-09-23 Impact factor: 4.256

5. Stimulation of glucose transport in osteoblastic cells by parathyroid hormone and insulin-like growth factor I.

Authors: E Zoidis; C Ghirlanda-Keller; C Schmid
Journal: Mol Cell Biochem Date: 2010-11-13 Impact factor: 3.396

6. A haplotype of MATN3 is associated with vertebral fracture in Chinese postmenopausal women: Peking Vertebral Fracture (PK-VF) study.

Authors: Jing Zhao; Weibo Xia; Min Nie; Xin Zheng; Qiuping Wang; Xiran Wang; Wenbo Wang; Zhiwei Ning; Wei Huang; Yan Jiang; Mei Li; Ou Wang; Xiaoping Xing; Yue Sun; Lianmei Luo; Shuli He; Wei Yu; Qiang Lin; Yu Pei; Fan Zhang; Youxia Han; Yanmin Tong; Ying Che; Ruixin Shen; Yingying Hu; Xueying Zhou; Qian Chen; Ling Xu
Journal: Bone Date: 2012-01-16 Impact factor: 4.398