Literature DB >> 10968274

Synthesis, spectroscopic characterization and biological properties of new natural aldehydes thiosemicarbazones.

P Tarasconi1, S Capacchi, G Pelosi, M Cornia, R Albertini, A Bonati, P P Dall'Aglio, P Lunghi, S Pinelli.   

Abstract

As part of a research programme aimed at the synthesis of compounds with antiviral, antibacterial and antitumor properties and their spectroscopic characterization, new thiosemicarbazones deriving from natural aldehydes have been investigated. These substances contain in the same molecule both a chain with nucleophilic centres N, S with tubercolostatic activity, and a glycosidic or alkyl moiety (modified glycosides and nucleosides have recently received a great deal of attention in the fields of neoplastic diseases and viral infections). In this paper the synthesis and the characterization of these compounds by means of 1H NMR, IR, and MS techniques is reported. Biological studies have involved both inhibition of cell proliferation and apoptosis tests on human leukemia cell line U937.

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Year:  2000        PMID： 10968274     DOI： 10.1016/s0968-0896(99)00260-6

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

Authors:  Shayna Sandhaus; Rosella Taylor; Tiffany Edwards; Alexis Huddleston; Ykeysha Wooten; Ramaiyer Venkatraman; Ralph T Weber; Antonio González-Sarrías; Patrick M Martin; Patrice Cagle; Yuk-Ching Tse-Dinh; Stephen J Beebe; Navindra Seeram; Alvin A Holder
Journal:  Inorg Chem Commun       Date:  2016-02       Impact factor: 2.495

2.  Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands.

Authors:  Nerissa A Lewis; Fange Liu; Luke Seymour; Anthony Magnusen; Travis R Erves; Jessa Faye Arca; Floyd A Beckford; Ramaiyer Venkatraman; Antonio González-Sarrías; Frank R Fronczek; Don G Vanderveer; Navindra P Seeram; Aimin Liu; William L Jarrett; Alvin A Holder
Journal:  Eur J Inorg Chem       Date:  2012-02-01       Impact factor: 2.524

3.  Ethyl 2-[(carbamothioyl-amino)-imino]-propano-ate.

Authors:  Charlane C Corrêa; José Eugênio J C Graúdo; Luiz Fernando C de Oliveira; Mauro V de Almeida; Renata Diniz
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-09

4.  Synthesis and crystal structure of ((E)-{2-[(E)-(4-hy-droxynaphthalen-1-yl)methyl-idene]hydrazin-1-yl}(methyl-sulfan-yl)methyl-idene)azanium hydrogen sulfate monohydrate.

Authors:  Oussama Nehar; Samira Louhibi; Leila Boukli-Hacene; Thierry Roisnel
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-08-26

5.  Synthesis of novel highly functionalized 4-thiazolidinone derivatives from 4-phenyl-3-thiosemicarbazones.

Authors:  Abdelmadjid Benmohammed; Omar Khoumeri; Ayada Djafri; Thierry Terme; Patrice Vanelle
Journal:  Molecules       Date:  2014-03-11       Impact factor: 4.411

6.  Cu(II), Ni(II), and Zn(II) Complexes of Salan-Type Ligand Containing Ester Groups: Synthesis, Characterization, Electrochemical Properties, and In Vitro Biological Activities.

Authors:  P Jeslin Kanaga Inba; B Annaraj; S Thalamuthu; M A Neelakantan
Journal:  Bioinorg Chem Appl       Date:  2013-07-25       Impact factor: 7.778

7.  Synthesis and antibacterial and antifungal activities of N-(tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of substituted 4-formylsydnones.

Authors:  Nguyen Dinh Thanh; Hoang Thanh Duc; Vu Thi Duyen; Phan Manh Tuong; Nguyen Van Quoc
Journal:  Chem Cent J       Date:  2015-10-19       Impact factor: 4.215
  7 in total

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