Literature DB >> 26752972

A novel copper(II) complex identified as a potent drug against colorectal and breast cancer cells and as a poison inhibitor for human topoisomerase IIα.

Shayna Sandhaus1, Rosella Taylor2, Tiffany Edwards2, Alexis Huddleston2, Ykeysha Wooten2, Ramaiyer Venkatraman3, Ralph T Weber4, Antonio González-Sarrías5, Patrick M Martin6, Patrice Cagle6, Yuk-Ching Tse-Dinh7, Stephen J Beebe8, Navindra Seeram5, Alvin A Holder9.   

Abstract

A novel complex, [Cu(acetylethTSC)Cl]Cl•0.25C2H5OH 1 (where acetylethTSC = (E)-N-ethyl-2-[1-(thiazol-2-yl)ethylidene]hydrazinecarbothioamide), was shown to have anti-proliferative activity against various colon and aggressive breast cancer cell lines. In vitro studies showed that complex 1 acted as a poison inhibitor of human topoisomerase IIα, which may account for the observed anti-cancer effects.

Entities:  

Keywords:  ESR spectroscopy; breast cancer; copper(II); cyclic voltammetry; human topoisomerase Iiα; thiosemicarbazones

Year:  2016        PMID： 26752972      PMCID： PMC4704796          DOI： 10.1016/j.inoche.2015.12.013

Source DB:  PubMed          Journal:  Inorg Chem Commun        ISSN： 1387-7003            Impact factor:   2.495


  39 in total

1.  Photocleavage of Nucleic Acids.

Authors:  Bruce Armitage
Journal:  Chem Rev       Date:  1998-05-07       Impact factor: 60.622

2.  Effects of terminal dimethylation and metal coordination of proline-2-formylpyridine thiosemicarbazone hybrids on lipophilicity, antiproliferative activity, and hR2 RNR inhibition.

Authors:  Felix Bacher; Orsolya Dömötör; Maria Kaltenbrunner; Miloš Mojović; Ana Popović-Bijelić; Astrid Gräslund; Andrew Ozarowski; Lana Filipovic; Sinisa Radulović; Éva A Enyedy; Vladimir B Arion
Journal:  Inorg Chem       Date:  2014-11-12       Impact factor: 5.165

Review 3.  N-heterocyclic carbene metal complexes as bio-organometallic antimicrobial and anticancer drugs.

Authors:  Siddappa A Patil; Shivaputra A Patil; Renukadevi Patil; Rangappa S Keri; Srinivasa Budagumpi; Geetha R Balakrishna; Matthias Tacke
Journal:  Future Med Chem       Date:  2015       Impact factor: 3.808

4.  Highly potent anti-proliferative effects of a gallium(III) complex with 7-chloroquinoline thiosemicarbazone as a ligand: synthesis, cytotoxic and antimalarial evaluation.

Authors:  Kewal Kumar; Sarah Schniper; Antonio González-Sarrías; Alvin A Holder; Natalie Sanders; David Sullivan; William L Jarrett; Krystyn Davis; Fengwei Bai; Navindra P Seeram; Vipan Kumar
Journal:  Eur J Med Chem       Date:  2014-08-16       Impact factor: 6.514

Review 5.  Towards new transition metal-based hypoxic selective agents for therapy and imaging.

Authors:  P J Blower; J R Dilworth; R I Maurer; G D Mullen; C A Reynolds; Y Zheng
Journal:  J Inorg Biochem       Date:  2001-05       Impact factor: 4.155

6.  Synthesis, characterization, and preliminary in vitro studies of vanadium(IV) complexes with a Schiff base and thiosemicarbazones as mixed-ligands.

Authors:  Nerissa A Lewis; Fange Liu; Luke Seymour; Anthony Magnusen; Travis R Erves; Jessa Faye Arca; Floyd A Beckford; Ramaiyer Venkatraman; Antonio González-Sarrías; Frank R Fronczek; Don G Vanderveer; Navindra P Seeram; Aimin Liu; William L Jarrett; Alvin A Holder
Journal:  Eur J Inorg Chem       Date:  2012-02-01       Impact factor: 2.524

Review 7.  Therapeutic gold, silver, and platinum nanoparticles.

Authors:  Miko Yamada; Matthew Foote; Tarl W Prow
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2014-12-17

Review 8.  Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes--molecular basis for combination chemotherapy in cancer.

Authors:  Tero A H Järvinen; Edison T Liu
Journal:  Curr Cancer Drug Targets       Date:  2006-11       Impact factor: 3.428

Review 9.  Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals.

Authors:  Brett M Paterson; Paul S Donnelly
Journal:  Chem Soc Rev       Date:  2011-03-15       Impact factor: 54.564

10.  Novel, quinone-thiosemicarbazone hybrid (QTSCHY) non-platinum antitumor agents: inhibition of DNA biosynthesis in P388 lymphocytic cells by coordinatively unsaturated copper(II) and iron(III) complexes of naphthoquinone thiosemicarbazones.

Authors:  S Padhye; R Chikate; A Kumbhar; J M Shallom; M P Chitnis
Journal:  Biometals       Date:  1992       Impact factor: 2.949
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  4 in total

1.  Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cells Growth via Downregulating Sp1 and Sp3 Transcription Factors.

Authors:  Myrna Hurtado; Umesh T Sankpal; Aboubacar Kaba; Shahela Mahammad; Jaya Chhabra; Deondra T Brown; Raj K Gurung; Alvin A Holder; Jamboor K Vishwanatha; Riyaz Basha
Journal:  Cell Physiol Biochem       Date:  2018-11-30

2.  Preparation, characterization, and anticancer efficacy of novel cobalt oxide nanoparticles conjugated with thiosemicarbazide.

Authors:  Mahsa Jarestan; Kimia Khalatbari; Ayda Pouraei; Seyed Ataollah Sadat Shandiz; Sadaf Beigi; Mohammad Hedayati; Amitis Majlesi; Fatemeh Akbari; Ali Salehzadeh
Journal:  3 Biotech       Date:  2020-05-05       Impact factor: 2.406

3.  Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities.

Authors:  Yu-Ting Wang; Yan Fang; Meng Zhao; Ming-Xue Li; Yu-Mei Ji; Qiu-Xia Han
Journal:  Medchemcomm       Date:  2017-10-09       Impact factor: 3.597

4.  Bioactive Salen-type Schiff Base Transition Metal Complexes as Possible Anticancer Agents.

Authors:  Maryam Damercheli; Mahdi Mahdi; Bita Mehravi; Mehdi Shafiee Ardestani
Journal:  Iran J Pharm Res       Date:  2019       Impact factor: 1.696
  4 in total

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