BACKGROUND/AIMS: The visual loss associated with compression of the optic chiasm by pituitary tumours may be transient or permanent, possibly related to the extent of irreversible retrograde degeneration to the retinal ganglion cells. The pattern electroretinogram (PERG) N95 component is thought to rise in relation to retinal ganglion cell function and hence may be a potential prognostic indicator for visual function following decompressive surgery. METHODS: The notes and electrodiagnostic records of 72 eyes from 36 patients with chiasmal compression were retrospectively analysed. RESULTS: The postoperative change in visual field was found to be associated with the PERG N95:P50 ratio (p=0.01). Improvement in visual field was shown by a greater proportion of eyes with a normal N95:P50 ratio (65%) than with an abnormal ratio (27%). No change in visual field occurred in 26% of the eyes with a normal N95:P50 ratio compared with 67% of those with an abnormal ratio. Only 8% of eyes showed a worsening of visual field following surgery, in similar proportions for eyes with normal and abnormal N95:P50 ratios. There was no significant relationship with visual acuity. CONCLUSION: The PERG is a useful visual prognostic indicator in the preoperative assessment of chiasmal compression.
BACKGROUND/AIMS: The visual loss associated with compression of the optic chiasm by pituitary tumours may be transient or permanent, possibly related to the extent of irreversible retrograde degeneration to the retinal ganglion cells. The pattern electroretinogram (PERG) N95 component is thought to rise in relation to retinal ganglion cell function and hence may be a potential prognostic indicator for visual function following decompressive surgery. METHODS: The notes and electrodiagnostic records of 72 eyes from 36 patients with chiasmal compression were retrospectively analysed. RESULTS: The postoperative change in visual field was found to be associated with the PERG N95:P50 ratio (p=0.01). Improvement in visual field was shown by a greater proportion of eyes with a normal N95:P50 ratio (65%) than with an abnormal ratio (27%). No change in visual field occurred in 26% of the eyes with a normal N95:P50 ratio compared with 67% of those with an abnormal ratio. Only 8% of eyes showed a worsening of visual field following surgery, in similar proportions for eyes with normal and abnormal N95:P50 ratios. There was no significant relationship with visual acuity. CONCLUSION: The PERG is a useful visual prognostic indicator in the preoperative assessment of chiasmal compression.
Authors: Mário L R Monteiro; Kenzo Hokazono; Leonardo P Cunha; Maria K Oyamada Journal: Graefes Arch Clin Exp Ophthalmol Date: 2012-09-29 Impact factor: 3.117
Authors: Archana A Gupta; Di Ding; Richard K Lee; Robert B Levy; Sanjoy K Bhattacharya Journal: Invest Ophthalmol Vis Sci Date: 2012-02-13 Impact factor: 4.799
Authors: David A Paul; Elon Gaffin-Cahn; Eric B Hintz; Giscard J Adeclat; Tong Zhu; Zoë R Williams; G Edward Vates; Bradford Z Mahon Journal: Sci Transl Med Date: 2014-12-10 Impact factor: 17.956