Ji-Sun Moon1, Sun Young Shin2. 1. Department of Ophthalmology, SahmYook Medical Center, 82 Mangu-ro, Dongdaemun-gu, Seoul, 02500, Republic of Korea. 2. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. eyeshin@catholic.ac.kr.
Abstract
AIMS: To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function. METHODS: A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer. RESULTS: The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = -0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness. CONCLUSION: During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery.
AIMS: To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function. METHODS: A total of 47 (PApatients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PApatients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer. RESULTS: The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = -0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness. CONCLUSION: During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery.
Authors: Akiyasu Kanamori; Maria-Magdalena Catrinescu; Jonathan M Belisle; Santiago Costantino; Leonard A Levin Journal: Am J Pathol Date: 2012-05-26 Impact factor: 4.307
Authors: Helen V Danesh-Meyer; Taras Papchenko; Peter J Savino; Andrew Law; James Evans; Greg D Gamble Journal: Invest Ophthalmol Vis Sci Date: 2008-02-08 Impact factor: 4.799
Authors: Hercules R Freitas; Gabriel Ferraz; Gustavo C Ferreira; Victor T Ribeiro-Resende; Luciana B Chiarini; José Luiz M do Nascimento; Karen Renata H Matos Oliveira; Tiago de Lima Pereira; Leonardo G B Ferreira; Regina C Kubrusly; Robson X Faria; Anderson Manoel Herculano; Ricardo A de Melo Reis Journal: PLoS One Date: 2016-04-14 Impact factor: 3.240
Authors: Mélissa Santorini; Thomas Ferreira De Moura; Sara Barraud; Claude Fabien Litré; Catherine Brugniart; Alexandre Denoyer; Zoubir Djerada; Carl Arndt Journal: Eye Brain Date: 2022-03-05