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Literature DB >> 109565

Determination of the kappa anti-alpha(1,3) dextran immune response difference by A gene(s) in the VKappa-locus of mice.

Abstract

Mice lacking the V(alpha(1,3) (h gamma1)-gene do not produce a gamma1 anti-alpha(1,3) dextran response. However, on hyperimmunization some strains mount a kappa-anti-alpha(1,3) dextran response, whereas other remain nonresponder. Responsiveness in dominant. The kappa-anti-alpha(1,3) response difference is linked to the Ly-3 locus on chromosone 6 and is likely the result of a structural Vkappa-gene(s). In conjunction with previous work, three Vkappa-allogroups can now be distinguished. At present, this is the only example of an immune responsiveness difference associated with the Vkappa-locus.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1979 PMID： 109565 PMCID： PMC2184877 DOI： 10.1084/jem.149.5.1265

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

12 in total

1. Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

Authors: H Hengartner; T Meo; E Müller
Journal: Proc Natl Acad Sci U S A Date: 1978-09 Impact factor: 11.205

2. Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

Authors: J A Laskin; A Gray; A Nisonoff; N R Klinman; P D Gottlieb
Journal: Proc Natl Acad Sci U S A Date: 1977-10 Impact factor: 11.205

3. Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.

Authors: E A Boyse; K Itakura; E Stockert; C A Iritani; M Miura
Journal: Transplantation Date: 1971-03 Impact factor: 4.939

4. The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.

Authors: P D Gottlieb; P J Durda
Journal: Cold Spring Harb Symp Quant Biol Date: 1977

Review 1. Mouse chromosome 12.

Authors: P D'Eustachio
Journal: Mamm Genome Date: 1992 Impact factor: 2.957

2. Recombination between kappa chain genetic markers and the Lyt-3 locus.

Authors: D M Gibson; S J Maclean; M Cherry
Journal: Immunogenetics Date: 1983 Impact factor: 2.846

3. BALB/c antiarsonate idiotypes: gene complementation necessary for expression.

Authors: A R Brown; P D Gottlieb
Journal: Immunogenetics Date: 1984 Impact factor: 2.846

4. Induction of a cross-reactive idiotype dextran-positive antibody response in two IgH-Cb mouse strains treated with anti-J558 cross-reactive idiotype antibodies.

Authors: J Pène; F Bekkhoucha; C Desaymard; H Zaghouani; M Stanislawski
Journal: J Exp Med Date: 1983-05-01 Impact factor: 14.307

4 in total

Determination of the kappa anti-alpha(1,3) dextran immune response difference by A gene(s) in the VKappa-locus of mice.

1. Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.

2. Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

3. Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.

4. The IB-peptide marker and the Ly-3 surface alloantigen: structural studies of a V kappa-region polymorphism and a T-cell marker determined by linked genes.

5. On the genetic dissection of a specific humoral immune response to alpha(1,3) dextran.

6. Genetics of the antibody response to dextran in mice.

7. A genetic marker in the variable region of light chains of mouse immunoglobulins.

8. On a regulatory gene controlling the expression of the murine lambda1 light chain.

9. Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

10. Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.

Review 1. Mouse chromosome 12.

2. Recombination between kappa chain genetic markers and the Lyt-3 locus.

3. BALB/c antiarsonate idiotypes: gene complementation necessary for expression.

4. Induction of a cross-reactive idiotype dextran-positive antibody response in two IgH-Cb mouse strains treated with anti-J558 cross-reactive idiotype antibodies.