Literature DB >> 819613

Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.

D Gibson.   

Abstract

Light chains isolated from normal immunoglobulin of unimmunized mice were analyzed by gel isoelectric focusing. Examination of the focusing patterns of light chains from nine inbred mouse strains showed that six of the strains (SWR/J, C3H/HeJ, DBA/1J, A/J, CBA/J, and C57BL/6J) possessed a virtually identical spectrum of focusing bands, while the remaining three strains (RF/J, AKR/J, and C58/J) showed clear differences involving several bands. Analysis of the light chains of individual SWR/J, C58/J, and F1 hybrid mice indicated that the differences in focusing pattern were inherited in a simple codominant fashion. A new procedure was developed for the rapid analysis of light chains from small quantities of serum.

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Year:  1976        PMID： 819613      PMCID： PMC2190346          DOI： 10.1084/jem.144.1.298

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  12 in total

1.  Studies on structural units of the gamma-globulins.

Authors:  G M EDELMAN; M D POULIK
Journal:  J Exp Med       Date:  1961-05-01       Impact factor: 14.307

2.  Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults.

Authors:  O SMITHIES
Journal:  Biochem J       Date:  1955-12       Impact factor: 3.857

3.  Isoelectric focusing of proteins in polyacrylamide gels.

Authors:  O Vesterberg
Journal:  Biochim Biophys Acta       Date:  1972-01-26

4.  Structural studies on normal horse immunoglobulin light chains. Detection of k-type N-terminal sequences.

Authors:  D Gibson
Journal:  Biochemistry       Date:  1974-06-18       Impact factor: 3.162

5.  Mouse immunoglobulin chains. A survey of the amino-terminal sequences of kappa chains.

Authors:  L Hood; D McKean; V Farnsworth; M Potter
Journal:  Biochemistry       Date:  1973-02       Impact factor: 3.162

6.  Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse.

Authors:  K Itakura; J J Hutton; E A Boyse; L J Old
Journal:  Transplantation       Date:  1972-03       Impact factor: 4.939

Review 7.  The organization, expression, and evolution of antibody genes and other multigene families.

Authors:  L Hood; J H Campbell; S C Elgin
Journal:  Annu Rev Genet       Date:  1975       Impact factor: 16.830

8.  A genetic marker in the variable region of light chains of mouse immunoglobulins.

Authors:  G M Edelman; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1970-11       Impact factor: 11.205

9.  Idiotype expression and the inheritance of mouse antibody clones.

Authors:  K Eichmann
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307

10.  Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

Authors:  P D Gottlieb
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307
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  25 in total

1.  Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.

Authors:  R T Boyd; M M Goldrick; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1986-12       Impact factor: 11.205

2.  Polymorphism in V kappa 10 genes encoding L chains of antibodies bearing the Ars-A and A48 cross-reactive idiotypes.

Authors:  S O Kim; I Sanz; C Williams; J D Capra; P D Gottlieb
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

3.  Identity of the V kappa 10-Ars-A gene segments of the A/J and BALB/c strains.

Authors:  K Meek; I Sanz; G Rathbun; A Nisonoff; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1987-09       Impact factor: 11.205

4.  Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

Authors:  J A Laskin; A Gray; A Nisonoff; N R Klinman; P D Gottlieb
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205

5.  Genetic polymorphism at the mouse immunoglobulin J kappa locus (Igk-J) as demonstrated by Southern hybridization and nucleotide sequence analysis.

Authors:  R T Boyd; M M Goldrick; P D Gottlieb
Journal:  Immunogenetics       Date:  1986       Impact factor: 2.846

6.  Molecular characterization of monoclonal CRIA-positive anti-arsonate antibodies derived from idiotype-negative mice bearing a light chain polymorphism.

Authors:  J Tassignon; M Brait; J Ismaili; J Urbain; P Gottlieb; A Brown; C A Hasemann; J D Capra; K Meek
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

7.  Recombination between kappa chain genetic markers and the Lyt-3 locus.

Authors:  D M Gibson; S J Maclean; M Cherry
Journal:  Immunogenetics       Date:  1983       Impact factor: 2.846

8.  Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype.

Authors:  M Siegelman; J D Capra
Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

9.  Comparison of the properties of the alcohol dehydrogenases from wild-type and mutant Chinese hamster somatic cells.

Authors:  B G Talbot; J P Thirion
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

10.  BALB/c antiarsonate idiotypes: gene complementation necessary for expression.

Authors:  A R Brown; P D Gottlieb
Journal:  Immunogenetics       Date:  1984       Impact factor: 2.846
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