Literature DB >> 10837023

The protein encoded by the proto-oncogene DEK changes the topology of chromatin and reduces the efficiency of DNA replication in a chromatin-specific manner.

V Alexiadis1, T Waldmann, J Andersen, M Mann, R Knippers, C Gruss.   

Abstract

The structure of chromatin regulates the genetic activity of the underlying DNA sequence. We report here that the protein encoded by the proto-oncogene DEK, which is involved in acute myelogenous leukemia, induces alterations of the superhelical density of DNA in chromatin. The change in topology is observed with chromatin but not with naked DNA and does not involve dissociation of core histones from chromatin. Moreover, these effects require histone H2A/H2B dimers in addition to histone H3/H4. We additionally tested whether the DEK protein affects DNA-utilizing processes and found that the DEK protein substantially reduces the replication efficiency of chromatin but not of naked DNA templates.

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Year:  2000        PMID： 10837023      PMCID： PMC316669     

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  36 in total

Review 1.  Chromatin-modifying and -remodeling complexes.

Authors:  R D Kornberg; Y Lorch
Journal:  Curr Opin Genet Dev       Date:  1999-04       Impact factor: 5.578

2.  Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.

Authors:  J K Tong; C A Hassig; G R Schnitzler; R E Kingston; S L Schreiber
Journal:  Nature       Date:  1998-10-29       Impact factor: 49.962

3.  Requirement of RSF and FACT for transcription of chromatin templates in vitro.

Authors:  G LeRoy; G Orphanides; W S Lane; D Reinberg
Journal:  Science       Date:  1998-12-04       Impact factor: 47.728

4.  NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

Authors:  Y Xue; J Wong; G T Moreno; M K Young; J Côté; W Wang
Journal:  Mol Cell       Date:  1998-12       Impact factor: 17.970

5.  Use of selectively trypsinized nucleosome core particles to analyze the role of the histone "tails" in the stabilization of the nucleosome.

Authors:  J Ausio; F Dong; K E van Holde
Journal:  J Mol Biol       Date:  1989-04-05       Impact factor: 5.469

6.  Chemical cross-linking of histones.

Authors:  J O Thomas
Journal:  Methods Enzymol       Date:  1989       Impact factor: 1.600

7.  The histone H3/H4.N1 complex supplemented with histone H2A-H2B dimers and DNA topoisomerase I forms nucleosomes on circular DNA under physiological conditions.

Authors:  K Zucker; A Worcel
Journal:  J Biol Chem       Date:  1990-08-25       Impact factor: 5.157

8.  The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA.

Authors:  M von Lindern; M Fornerod; S van Baal; M Jaegle; T de Wit; A Buijs; G Grosveld
Journal:  Mol Cell Biol       Date:  1992-04       Impact factor: 4.272

9.  Transfer of nucleosomes from parental to replicated chromatin.

Authors:  T Krude; R Knippers
Journal:  Mol Cell Biol       Date:  1991-12       Impact factor: 4.272

10.  Disruption of the nucleosomes at the replication fork.

Authors:  C Gruss; J Wu; T Koller; J M Sogo
Journal:  EMBO J       Date:  1993-12       Impact factor: 11.598
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  66 in total

1.  The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions.

Authors:  H Le Hir; E Izaurralde; L E Maquat; M J Moore
Journal:  EMBO J       Date:  2000-12-15       Impact factor: 11.598

2.  A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila.

Authors:  X Morin; R Daneman; M Zavortink; W Chia
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-11       Impact factor: 11.205

3.  Transcriptional activation by AP-2alpha is modulated by the oncogene DEK.

Authors:  Mónica Campillos; Miguel Angel García; Fernando Valdivieso; Jesús Vázquez
Journal:  Nucleic Acids Res       Date:  2003-03-01       Impact factor: 16.971

4.  Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes.

Authors:  Anita Krithivas; Masahiro Fujimuro; Magdalena Weidner; David B Young; S Diane Hayward
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

5.  Chromatin assembly factor 1 is essential and couples chromatin assembly to DNA replication in vivo.

Authors:  Maarten Hoek; Bruce Stillman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-30       Impact factor: 11.205

6.  Structure-specific binding of the proto-oncogene protein DEK to DNA.

Authors:  Tanja Waldmann; Martina Baack; Nicole Richter; Claudia Gruss
Journal:  Nucleic Acids Res       Date:  2003-12-01       Impact factor: 16.971

7.  The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.

Authors:  Fabrice Lejeune; Yasuhito Ishigaki; Xiaojie Li; Lynne E Maquat
Journal:  EMBO J       Date:  2002-07-01       Impact factor: 11.598

8.  Phosphorylation by protein kinase CK2 changes the DNA binding properties of the human chromatin protein DEK.

Authors:  Ferdinand Kappes; Catalina Damoc; Rolf Knippers; Michael Przybylski; Lorenzo A Pinna; Claudia Gruss
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

9.  Functional domains of the ubiquitous chromatin protein DEK.

Authors:  Ferdinand Kappes; Ingo Scholten; Nicole Richter; Claudia Gruss; Tanja Waldmann
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

Review 10.  Control of tumorigenesis and chemoresistance by the DEK oncogene.

Authors:  Erica Riveiro-Falkenbach; María S Soengas
Journal:  Clin Cancer Res       Date:  2010-05-25       Impact factor: 12.531
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