Literature DB >> 10770776

Pharmacokinetics and pharmacodynamics of levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in human skin blister fluid.

A Trampuz1, M Wenk, Z Rajacic, W Zimmerli.   

Abstract

The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

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Year:  2000        PMID： 10770776      PMCID： PMC89869          DOI： 10.1128/AAC.44.5.1352-1355.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Pharmacokinetics and inflammatory fluid penetration of sparfloxacin.

Authors:  J H Johnson; M A Cooper; J M Andrews; R Wise
Journal:  Antimicrob Agents Chemother       Date:  1992-11       Impact factor: 5.191

2.  In vitro demonstration of transport and delivery of antibiotics by polymorphonuclear leukocytes.

Authors:  M O Frank; G W Sullivan; H T Carper; G L Mandell
Journal:  Antimicrob Agents Chemother       Date:  1992-12       Impact factor: 5.191

3.  Comparative in-vitro activity of levofloxacin against Chlamydia spp.

Authors:  M Donati; F Rumpianesi; F Marchetti; V Sambri; R Cevenini
Journal:  J Antimicrob Chemother       Date:  1998-11       Impact factor: 5.790

Review 4.  Tissue-directed antibiotics and intracellular parasites: complex interaction of phagocytes, pathogens, and drugs.

Authors:  G R Donowitz
Journal:  Clin Infect Dis       Date:  1994-11       Impact factor: 9.079

5.  The comparative pharmacokinetics and tissue penetration of single-dose ciprofloxacin 400 mg i.v. and 750 mg po.

Authors:  C Catchpole; J M Andrews; J Woodcock; R Wise
Journal:  J Antimicrob Chemother       Date:  1994-01       Impact factor: 5.790

6.  The in-vitro activity, pharmacokinetics and tissue penetration of temafloxacin.

Authors:  K Nye; Y G Shi; J M Andrews; J P Ashby; R Wise
Journal:  J Antimicrob Chemother       Date:  1989-09       Impact factor: 5.790

7.  Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms.

Authors:  J F Hoogkamer; W H Hesse; S Sansano; W Zimmerli
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

8.  Uptake and intracellular activity of an optically active ofloxacin isomer in human neutrophils and tissue culture cells.

Authors:  A Pascual; I Garcia; E J Perea
Journal:  Antimicrob Agents Chemother       Date:  1990-02       Impact factor: 5.191

Review 9.  Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy.

Authors:  R Davis; H M Bryson
Journal:  Drugs       Date:  1994-04       Impact factor: 9.546

10.  Persistent bacteremia in staphylococcal endocarditis.

Authors:  M T Reymann; H P Holley; C G Cobbs
Journal:  Am J Med       Date:  1978-11       Impact factor: 4.965
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  11 in total

1.  Pharmacokinetics and pharmacodynamics of gatifloxacin against Streptococcus pneumoniae and Staphylococcus aureus in a granulocyte-rich exudate.

Authors:  Andrej Trampuz; Gerd Laifer; Markus Wenk; Zarko Rajacic; Werner Zimmerli
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

2.  Efficacy of usual and high doses of daptomycin in combination with rifampin versus alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.

Authors:  C Garrigós; O Murillo; G Euba; R Verdaguer; F Tubau; C Cabellos; J Cabo; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2010-10-04       Impact factor: 5.191

3.  Electroporation and transcutaneous sampling (ETS) of acyclovir.

Authors:  S Narasimha Murthy; Shuangqing Zhang
Journal:  J Dermatol Sci       Date:  2007-10-18       Impact factor: 4.563

4.  Antagonistic effect of rifampin on the efficacy of high-dose levofloxacin in staphylococcal experimental foreign-body infection.

Authors:  O Murillo; M E Pachón; G Euba; R Verdaguer; F Tubau; C Cabellos; J Cabo; F Gudiol; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2008-08-01       Impact factor: 5.191

5.  Efficacy of high doses of levofloxacin in experimental foreign-body infection by methicillin-susceptible Staphylococcus aureus.

Authors:  O Murillo; A Doménech; A Garcia; F Tubau; C Cabellos; F Gudiol; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

6.  Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy.

Authors:  P Villani; P Viale; L Signorini; B Cadeo; F Marchetti; A Villani; C Fiocchi; M B Regazzi; G Carosi
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

7.  Efficacy of high doses of daptomycin versus alternative therapies against experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.

Authors:  O Murillo; C Garrigós; M E Pachón; G Euba; R Verdaguer; C Cabellos; J Cabo; F Gudiol; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2009-07-27       Impact factor: 5.191

8.  Efficacy of daptomycin-cloxacillin combination in experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.

Authors:  C Garrigós; O Murillo; J Lora-Tamayo; R Verdaguer; F Tubau; C Cabellos; J Cabo; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2012-05-14       Impact factor: 5.191

9.  Fosfomycin-daptomycin and other fosfomycin combinations as alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.

Authors:  C Garrigós; O Murillo; J Lora-Tamayo; R Verdaguer; F Tubau; C Cabellos; J Cabo; J Ariza
Journal:  Antimicrob Agents Chemother       Date:  2012-10-22       Impact factor: 5.191

10.  Pharmacokinetic/pharmacodynamic evaluation of antimicrobial treatments of orofacial odontogenic infections.

Authors:  Arantxa Isla; Andrés Canut; Alicia R Gascón; Alicia Labora; Bruno Ardanza-Trevijano; Maria Angelés Solinís; Jose Luis Pedraz
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 5.577
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