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Literature DB >> 10591654

Microarray analysis of Drosophila development during metamorphosis.

K P White¹, S A Rifkin, P Hurban, D S Hogness.

Abstract

Metamorphosis is an integrated set of developmental processes controlled by a transcriptional hierarchy that coordinates the action of hundreds of genes. In order to identify and analyze the expression of these genes, high-density DNA microarrays containing several thousand Drosophila melanogaster gene sequences were constructed. Many differentially expressed genes can be assigned to developmental pathways known to be active during metamorphosis, whereas others can be assigned to pathways not previously associated with metamorphosis. Additionally, many genes of unknown function were identified that may be involved in the control and execution of metamorphosis. The utility of this genome-based approach is demonstrated for studying a set of complex biological processes in a multicellular organism.

Entities: Gene Species

Mesh：

Substances：
Ecdysone

Year: 1999 PMID： 10591654 DOI： 10.1126/science.286.5447.2179

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

119 in total

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2. Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays.

Authors: R Miki; K Kadota; H Bono; Y Mizuno; Y Tomaru; P Carninci; M Itoh; K Shibata; J Kawai; H Konno; S Watanabe; K Sato; Y Tokusumi; N Kikuchi; Y Ishii; Y Hamaguchi; I Nishizuka; H Goto; H Nitanda; S Satomi; A Yoshiki; M Kusakabe; J L DeRisi; M B Eisen; V R Iyer; P O Brown; M Muramatsu; H Shimada; Y Okazaki; Y Hayashizaki
Journal: Proc Natl Acad Sci U S A Date: 2001-02-27 Impact factor: 11.205

3. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

Authors: S Zou; S Meadows; L Sharp; L Y Jan; Y N Jan
Journal: Proc Natl Acad Sci U S A Date: 2000-12-05 Impact factor: 11.205

4. Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays.

Authors: R Leemans; B Egger; T Loop; L Kammermeier; H He; B Hartmann; U Certa; F Hirth; H Reichert
Journal: Proc Natl Acad Sci U S A Date: 2000-10-24 Impact factor: 11.205

5. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation.

Authors: T Hock; T Cottrill; J Keegan; D Garza
Journal: Proc Natl Acad Sci U S A Date: 2000-08-15 Impact factor: 11.205

6. The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing.

Authors: Emmanuel Labourier; Marco Blanchette; Jennie W Feiger; Melissa D Adams; Donald C Rio
Journal: Genes Dev Date: 2002-01-01 Impact factor: 11.361

Microarray analysis of Drosophila development during metamorphosis.

1. Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography.

2. Delineating developmental and metabolic pathways in vivo by expression profiling using the RIKEN set of 18,816 full-length enriched mouse cDNA arrays.

3. Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

4. Quantitative transcript imaging in normal and heat-shocked Drosophila embryos by using high-density oligonucleotide arrays.

5. The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation.

6. The KH-type RNA-binding protein PSI is required for Drosophila viability, male fertility, and cellular mRNA processing.

7. A transcriptional roadmap to wood formation.

8. Development and evaluation of functional gene arrays for detection of selected genes in the environment.

9. Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways.

10. A question of size: the eukaryotic proteome and the problems in defining it.