Literature DB >> 11095759

Genome-wide study of aging and oxidative stress response in Drosophila melanogaster.

S Zou1, S Meadows, L Sharp, L Y Jan, Y N Jan.   

Abstract

Aging is a universal but poorly understood biological process. Free radicals accumulate with age and have been proposed to be a major cause of aging. We measured genome-wide changes in transcript levels as a function of age in Drosophila melanogaster and compared these changes with those caused by paraquat, a free-radical generator. A number of genes exhibited changes in transcript levels with both age and paraquat treatment. We also found genes whose transcript levels changed with age but not with paraquat treatment. This study suggests that free radicals play an important role in regulating transcript levels in aging but that they are not the only factors. This genome-wide survey also identifies candidates for molecular markers of aging.

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Year:  2000        PMID： 11095759      PMCID： PMC17643          DOI： 10.1073/pnas.260496697

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  33 in total

1.  Aging: a theory based on free radical and radiation chemistry.

Authors:  D HARMAN
Journal:  J Gerontol       Date:  1956-07

2.  Microarray analysis of Drosophila development during metamorphosis.

Authors:  K P White; S A Rifkin; P Hurban; D S Hogness
Journal:  Science       Date:  1999-12-10       Impact factor: 47.728

3.  Oxidative damage during aging targets mitochondrial aconitase.

Authors:  L J Yan; R L Levine; R S Sohal
Journal:  Proc Natl Acad Sci U S A       Date:  1997-10-14       Impact factor: 11.205

4.  Mitotic misregulation and human aging.

Authors:  D H Ly; D J Lockhart; R A Lerner; P G Schultz
Journal:  Science       Date:  2000-03-31       Impact factor: 47.728

Review 5.  Dietary restriction and aging: historical phases, mechanisms and current directions.

Authors:  R L Walford; S B Harris; R Weindruch
Journal:  J Nutr       Date:  1987-10       Impact factor: 4.798

6.  The p66shc adaptor protein controls oxidative stress response and life span in mammals.

Authors:  E Migliaccio; M Giorgio; S Mele; G Pelicci; P Reboldi; P P Pandolfi; L Lanfrancone; P G Pelicci
Journal:  Nature       Date:  1999-11-18       Impact factor: 49.962

7.  The complete amino acid sequence of three alcohol dehydrogenase alleloenzymes (AdhN-11, AdhS and AdhUF) from the fruitfly Drosophila melanogaster.

Authors:  D R Thatcher
Journal:  Biochem J       Date:  1980-06-01       Impact factor: 3.857

8.  Gene-expression profile of the ageing brain in mice.

Authors:  C K Lee; R Weindruch; T A Prolla
Journal:  Nat Genet       Date:  2000-07       Impact factor: 38.330

9.  A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans.

Authors:  J Z Morris; H A Tissenbaum; G Ruvkun
Journal:  Nature       Date:  1996-08-08       Impact factor: 49.962

10.  Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins.

Authors:  A Bito; M Haider; I Hadler; M Breitenbach
Journal:  J Biol Chem       Date:  1997-08-22       Impact factor: 5.157
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  102 in total

1.  Life extension in Drosophila by feeding a drug.

Authors:  Hyung-Lyun Kang; Seymour Benzer; Kyung-Tai Min
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-15       Impact factor: 11.205

2.  The computational analysis of scientific literature to define and recognize gene expression clusters.

Authors:  Soumya Raychaudhuri; Jeffrey T Chang; Farhad Imam; Russ B Altman
Journal:  Nucleic Acids Res       Date:  2003-08-01       Impact factor: 16.971

3.  The use of transcriptional profiles to predict adult mosquito age under field conditions.

Authors:  Peter E Cook; Leon E Hugo; Iñaki Iturbe-Ormaetxe; Craig R Williams; Stephen F Chenoweth; Scott A Ritchie; Peter A Ryan; Brian H Kay; Mark W Blows; Scott L O'Neill
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-16       Impact factor: 11.205

4.  Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster.

Authors:  Ming Zhan; Haruyoshi Yamaza; Yu Sun; Jason Sinclair; Huai Li; Sige Zou
Journal:  Genome Res       Date:  2007-07-10       Impact factor: 9.043

5.  Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes.

Authors:  John Tower; Gary Landis; Rebecca Gao; Albert Luan; Jonathan Lee; Yuanyue Sun
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2013-05-30       Impact factor: 6.053

Review 6.  Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?

Authors:  Raymond Chuen-Chung Chang; Kwok-Fai So
Journal:  Cell Mol Neurobiol       Date:  2007-08-21       Impact factor: 5.046

7.  The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors.

Authors:  Jean-Philippe David; Clare Strode; John Vontas; Dimitra Nikou; Ashley Vaughan; Patricia M Pignatelli; Christos Louis; Janet Hemingway; Hilary Ranson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-07       Impact factor: 11.205

8.  4E-BP functions as a metabolic brake used under stress conditions but not during normal growth.

Authors:  Aurelio A Teleman; Ya-Wen Chen; Stephen M Cohen
Journal:  Genes Dev       Date:  2005-08-15       Impact factor: 11.361

Review 9.  Involvement of redox state in the aging of Drosophila melanogaster.

Authors:  William C Orr; Svetlana N Radyuk; Rajindar S Sohal
Journal:  Antioxid Redox Signal       Date:  2013-04-06       Impact factor: 8.401

10.  Endogenously imprinted genes in Drosophila melanogaster.

Authors:  Lori A McEachern; Nicholas J Bartlett; Vett K Lloyd
Journal:  Mol Genet Genomics       Date:  2014-08       Impact factor: 3.291
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