Literature DB >> 5256225

A mutant of yeast apparently defective in the initiation of protein synthesis.

L H Hartwell, C S McLaughlin.   

Abstract

A temperature-sensitive mutant of yeast, ts(-)187, which is apparently unable to initiate the synthesis of new polypeptide chains after a short incubation at the restrictive temperature, is described. The existence of this mutant demonstrates that in eucaryotic cells, as in procaryotic cells, there are processes unique to the initiation of polypeptide chains.

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Year:  1969        PMID: 5256225      PMCID: PMC277822          DOI: 10.1073/pnas.62.2.468

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  8 in total

1.  A genetic locus for the regulation of ribonucleic acid synthesis.

Authors:  G S STENT; S BRENNER
Journal:  Proc Natl Acad Sci U S A       Date:  1961-12-15       Impact factor: 11.205

2.  Translation of the genetic message, ii. Effect of initiation factors on the binding of formyl-methionyl-trna to ribosomes.

Authors:  M Salas; M B Hille; J A Last; A J Wahba; S Ochoa
Journal:  Proc Natl Acad Sci U S A       Date:  1967-02       Impact factor: 11.205

3.  Role of protein factor in the functional binding of ribosomes to natural messenger RNA.

Authors:  M Revel; M Herzberg; A Becarevic; F Gros
Journal:  J Mol Biol       Date:  1968-04-14       Impact factor: 5.469

4.  Initiation of polyphenylalanine synthesis by N-acetylphenylalanyl-SRNA.

Authors:  J Lucas-Lenard; F Lipmann
Journal:  Proc Natl Acad Sci U S A       Date:  1967-04       Impact factor: 11.205

5.  Temperature-sensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis.

Authors:  L H Hartwell; C S McLaughlin
Journal:  J Bacteriol       Date:  1968-11       Impact factor: 3.490

6.  N-formyl-methionyl-sigma-ribonucleic acid and chain initiation in protein biosynthesis. Polypeptide synthesis directed by a bacteriophage ribonucleic acid in a cell-free system.

Authors:  B F Clark; K A Marcker
Journal:  Nature       Date:  1966-07-23       Impact factor: 49.962

7.  Macromolecule synthesis in yeast spheroplasts.

Authors:  H T Hutchison; L H Hartwell
Journal:  J Bacteriol       Date:  1967-11       Impact factor: 3.490

8.  Macromolecule synthesis in temperature-sensitive mutants of yeast.

Authors:  L H Hartwell
Journal:  J Bacteriol       Date:  1967-05       Impact factor: 3.490

  8 in total
  58 in total

Review 1.  Growth and differentiation of the water mold Blastocladiella emersonii: cytodifferentiation and the role of ribonucleic acid and protein synthesis.

Authors:  J S Lovett
Journal:  Bacteriol Rev       Date:  1975-12

2.  Cellular content of ribonucleic acid and protein in Saccharomyces cerevisiae as a function of exponential growth rate: calculation of the apparent peptide chain elongation rate.

Authors:  K W Boehlke; J D Friesen
Journal:  J Bacteriol       Date:  1975-02       Impact factor: 3.490

3.  Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export.

Authors:  A K Azad; D R Stanford; S Sarkar; A K Hopper
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

4.  Autoregulation in the biosynthesis of ribosomes.

Authors:  Yu Zhao; Jung-Hoon Sohn; Jonathan R Warner
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272

5.  Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Authors:  M Ramirez; R C Wek; C R Vazquez de Aldana; B M Jackson; B Freeman; A G Hinnebusch
Journal:  Mol Cell Biol       Date:  1992-12       Impact factor: 4.272

Review 6.  Power of yeast for analysis of eukaryotic translation initiation.

Authors:  Michael Altmann; Patrick Linder
Journal:  J Biol Chem       Date:  2010-08-06       Impact factor: 5.157

7.  Complex formation by positive and negative translational regulators of GCN4.

Authors:  A M Cigan; M Foiani; E M Hannig; A G Hinnebusch
Journal:  Mol Cell Biol       Date:  1991-06       Impact factor: 4.272

8.  The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides.

Authors:  Matthias Gautschi; Sören Just; Andrej Mun; Suzanne Ross; Peter Rücknagel; Yves Dubaquié; Ann Ehrenhofer-Murray; Sabine Rospert
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

9.  Mapping CDC mutations in the yeast S. cerevisiae by rad52-mediated chromosome loss.

Authors:  P J Hanic-Joyce
Journal:  Genetics       Date:  1985-08       Impact factor: 4.562

10.  Efficient translation of an SSA1-derived heat-shock mRNA in yeast cells limited for cap-binding protein and eIF-4F.

Authors:  C A Barnes; M M MacKenzie; G C Johnston; R A Singer
Journal:  Mol Gen Genet       Date:  1995-03-10
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