Literature DB >> 10550850

Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.

C A Knibbe1, V S Koster, L P Aarts, H J Langemeijer, M Danhof.   

Abstract

In a pilot study on the first application of Propofol 6% SAZN in humans, the pharmacokinetics and safety of the new product seem to be similar to those of Propofol 1% SAZN and Diprivan-10 after bolus injection. The results will have to be confirmed in a larger clinical study in order to develop Propofol 6% SAZN as an alternative for Diprivan-10.

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Year:  1999        PMID： 10550850     DOI： 10.1023/a:1008701004814

Source DB:  PubMed          Journal:  Pharm World Sci        ISSN： 0928-1231


  10 in total

1.  Determination of propofol in low-volume samples by high-performance liquid chromatography with fluorescence detection.

Authors:  C A Knibbe; V S Koster; V H Deneer; R M Stuurman; P F Kuks; R Lange
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1998-03-20

2.  Propofol pharmacokinetics and pharmacodynamics assessed from a cremophor EL formulation.

Authors:  S Dutta; Y Matsumoto; W F Ebling
Journal:  J Pharm Sci       Date:  1997-08       Impact factor: 3.534

3.  Effect of prolonged sedation with propofol on serum triglyceride and cholesterol concentrations.

Authors:  M Gottardis; K S Khünl-Brady; W Koller; G Sigl; J M Hackl
Journal:  Br J Anaesth       Date:  1989-04       Impact factor: 9.166

4.  Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol.

Authors:  E H Cox; C A Knibbe; V S Koster; M W Langemeijer; E E Tukker; R Lange; P F Kuks; H J Langemeijer; L Lie-A-Huen; M Danhof
Journal:  Pharm Res       Date:  1998-03       Impact factor: 4.200

5.  Emulsion formulation reduces propofol's dose requirements and enhances safety.

Authors:  S Dutta; W F Ebling
Journal:  Anesthesiology       Date:  1997-12       Impact factor: 7.892

6.  Pharmacokinetics and pharmacodynamics of propofol in a new solvent.

Authors:  A W Doenicke; M F Roizen; J Rau; M O'Connor; J Kugler; U Klotz; J Babl
Journal:  Anesth Analg       Date:  1997-12       Impact factor: 5.108

Review 7.  Propofol. An update of its use in anaesthesia and conscious sedation.

Authors:  H M Bryson; B R Fulton; D Faulds
Journal:  Drugs       Date:  1995-09       Impact factor: 9.546

8.  Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.

Authors:  T J Parke; J E Stevens; A S Rice; C L Greenaway; R J Bray; P J Smith; C S Waldmann; C Verghese
Journal:  BMJ       Date:  1992-09-12

Review 9.  Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation.

Authors:  B Fulton; E M Sorkin
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546

10.  Dose requirements of ICI 35,868 (propofol, 'Diprivan') in a new formulation for induction of anaesthesia.

Authors:  G C Cummings; J Dixon; N H Kay; J P Windsor; E Major; M Morgan; J W Sear; A A Spence; D K Stephenson
Journal:  Anaesthesia       Date:  1984-12       Impact factor: 6.955
  10 in total

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