| Literature DB >> 6335003 |
G C Cummings, J Dixon, N H Kay, J P Windsor, E Major, M Morgan, J W Sear, A A Spence, D K Stephenson.
Abstract
In order to avoid Cremophor-related reactions and reduce the incidence of pain on injection, diisopropylphenol (ICI 35,868; propofol) has been reformulated as an emulsion. One hundred and fifteen patients received an induction dose of propofol in the new formulation. The dose required to induce anaesthesia in 95% of healthy, unpremedicated patients was 2.5 mg/kg. Induction was associated with a degree of cardiovascular and respiratory depression. There were no adverse reactions although there were a number of minor side-effects. The incidence of pain on injection was low (3%) and the overall quality of induction was assessed as good or adequate in 92% of patients.Entities:
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Year: 1984 PMID： 6335003 DOI： 10.1111/j.1365-2044.1984.tb06425.x
Source DB: PubMed Journal: Anaesthesia ISSN： 0003-2409 Impact factor: 6.955