Literature DB >> 9551817

Determination of propofol in low-volume samples by high-performance liquid chromatography with fluorescence detection.

C A Knibbe1, V S Koster, V H Deneer, R M Stuurman, P F Kuks, R Lange.   

Abstract

In order to determine propofol in rat whole-blood samples of 50 microl, we developed a rapid, simple and reliable method which is characterized by precipitation of blood elements with acetonitrile and submission of the supernatant to HPLC analysis with fluorescence detection. The method described is linear from 0.4 to 40 mg/l and the relative standard deviations in this concentration range are less than 10%. The limit of quantification proved to be 0.4 mg/l. Blood constituents do not interfere with the assay.

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Year:  1998        PMID： 9551817     DOI： 10.1016/s0378-4347(97)00571-9

Source DB:  PubMed          Journal:  J Chromatogr B Biomed Sci Appl        ISSN： 1387-2273


  16 in total

1.  Population pharmacokinetics and pharmacodynamics of propofol in morbidly obese patients.

Authors:  Simone van Kralingen; Jeroen Diepstraten; Mariska Y M Peeters; Vera H M Deneer; Bert van Ramshorst; René J Wiezer; Eric P A van Dongen; Meindert Danhof; Catherijne A J Knibbe
Journal:  Clin Pharmacokinet       Date:  2011-11-01       Impact factor: 6.447

Review 2.  The role of population PK-PD modelling in paediatric clinical research.

Authors:  Roosmarijn F W De Cock; Chiara Piana; Elke H J Krekels; Meindert Danhof; Karel Allegaert; Catherijne A J Knibbe
Journal:  Eur J Clin Pharmacol       Date:  2010-03-26       Impact factor: 2.953

3.  Population pharmacokinetic-pharmacodynamic modeling and dosing simulation of propofol maintenance anesthesia in severely obese adolescents.

Authors:  Vidya Chidambaran; Raja Venkatasubramanian; Senthilkumar Sadhasivam; Hope Esslinger; Shareen Cox; Jeroen Diepstraten; Tsuyoshi Fukuda; Thomas Inge; Catherijne A J Knibbe; Alexander A Vinks
Journal:  Paediatr Anaesth       Date:  2015-05-13       Impact factor: 2.556

4.  High-performance liquid chromatographic determination of propofol in human plasma: comparison of different heteroscedastic calibration curve models.

Authors:  Pooria Taghavi Moghaddam; Mohammad Reza Pipelzadeh; Sholeh Nesioonpour; Nader Saki; Saeed Rezaee
Journal:  Adv Pharm Bull       Date:  2014-08-10

5.  Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol.

Authors:  E H Cox; C A Knibbe; V S Koster; M W Langemeijer; E E Tukker; R Lange; P F Kuks; H J Langemeijer; L Lie-A-Huen; M Danhof
Journal:  Pharm Res       Date:  1998-03       Impact factor: 4.200

6.  Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN vs propofol 1% SAZN and Diprivan-10 after bolus injection.

Authors:  C A Knibbe; H J Voortman; L P Aarts; P F Kuks; R Lange; H J Langemeijer; M Danhof
Journal:  Br J Clin Pharmacol       Date:  1999-06       Impact factor: 4.335

7.  Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN.

Authors:  C A Knibbe; V S Koster; L P Aarts; H J Langemeijer; M Danhof
Journal:  Pharm World Sci       Date:  1999-10

8.  Propofol Clearance in Morbidly Obese Children and Adolescents : Influence of Age and Body Size.

Authors:  Jeroen Diepstraten; Vidya Chidambaran; Senthilkumar Sadhasivam; Hope R Esslinger; Shareen L Cox; Thomas H Inge; Catherijne A J Knibbe; Alexander A Vinks
Journal:  Clin Pharmacokinet       Date:  2012-08       Impact factor: 6.447

9.  Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients.

Authors:  Mariska Y M Peeters; Leon P H J Aarts; Ferenc A Boom; Leo J Bras; Dick Tibboel; Meindert Danhof; Catherijne A J Knibbe
Journal:  Eur J Clin Pharmacol       Date:  2007-11-13       Impact factor: 2.953

10.  Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery.

Authors:  Catherijne A J Knibbe; Gitte Melenhorst-de Jong; Maaike Mestrom; Carin M A Rademaker; Allart F A Reijnvaan; Klaas P Zuideveld; Paul F M Kuks; Hans van Vught; Meindert Danhof
Journal:  Br J Clin Pharmacol       Date:  2002-10       Impact factor: 4.335
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