Literature DB >> 10543772

Effects of F171 mutations in the 6'-N-acetyltransferase type Ib [AAC(6')-Ib] enzyme on susceptibility to aminoglycosides.

R Chavideh1, S Sholly, D Panaite, M E Tolmasky.   

Abstract

Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.

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Year:  1999        PMID： 10543772      PMCID： PMC89568     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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4.  Mutational analysis of receptor binding mediated by the Dr family of Escherichia coli adhesins.

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5.  Random mutagenesis used to probe the structure and function of Bacillus stearothermophilus alpha-amylase.

Authors:  L Holm; A K Koivula; P M Lehtovaara; A Hemminki; J K Knowles
Journal:  Protein Eng       Date:  1990-01

6.  Deciphering the message in protein sequences: tolerance to amino acid substitutions.

Authors:  J U Bowie; J F Reidhaar-Olson; W A Lim; R T Sauer
Journal:  Science       Date:  1990-03-16       Impact factor: 47.728

7.  Plasmid-encoded amikacin resistance in multiresistant strains of Klebsiella pneumoniae isolated from neonates with meningitis.

Authors:  M Woloj; M E Tolmasky; M C Roberts; J H Crosa
Journal:  Antimicrob Agents Chemother       Date:  1986-02       Impact factor: 5.191

8.  Tn1331, a novel multiresistance transposon encoding resistance to amikacin and ampicillin in Klebsiella pneumoniae.

Authors:  M E Tolmasky; J H Crosa
Journal:  Antimicrob Agents Chemother       Date:  1987-12       Impact factor: 5.191

9.  Thermosensitive mutants of Aspergillus awamori glucoamylase by random mutagenesis: inactivation kinetics and structural interpretation.

Authors:  N Flory; M Gorman; P M Coutinho; C Ford; P J Reilly
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Review 10.  Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.

Authors:  K J Shaw; P N Rather; R S Hare; G H Miller
Journal:  Microbiol Rev       Date:  1993-03
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  7 in total

1.  Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib.

Authors:  A Shmara; N Weinsetel; K J Dery; R Chavideh; M E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2001-12       Impact factor: 5.191

2.  Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Authors:  Kenward Vong; Karine Auclair
Journal:  Medchemcomm       Date:  2012-04-01       Impact factor: 3.597

3.  Aminoglycoside resistance resulting from tight drug binding to an altered aminoglycoside acetyltransferase.

Authors:  Sophie Magnet; Terry-Ann Smith; Renjian Zheng; Patrice Nordmann; John S Blanchard
Journal:  Antimicrob Agents Chemother       Date:  2003-05       Impact factor: 5.191

Review 4.  Aminoglycoside modifying enzymes.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Drug Resist Updat       Date:  2010-09-15       Impact factor: 18.500

5.  The aminoglycoside 6'-N-acetyltransferase type Ib encoded by Tn1331 is evenly distributed within the cell's cytoplasm.

Authors:  Ken J Dery; Britta Søballe; Mavee S L Witherspoon; Duyen Bui; Robert Koch; David J Sherratt; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2003-09       Impact factor: 5.191

6.  Inhibition of aminoglycoside 6'-N-acetyltransferase type Ib-mediated amikacin resistance by antisense oligodeoxynucleotides.

Authors:  Renee Sarno; Hongphuc Ha; Natalia Weinsetel; Marcelo E Tolmasky
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

7.  Rise and dissemination of aminoglycoside resistance: the aac(6')-Ib paradigm.

Authors:  María S Ramirez; Nikolas Nikolaidis; Marcelo E Tolmasky
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  7 in total

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