Literature DB >> 28018574

Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Kenward Vong1, Karine Auclair1.   

Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'-N-acetyltransferase (AAC(6')).

Entities:  

Year:  2012        PMID： 28018574      PMCID： PMC5179255          DOI： 10.1039/C2MD00253A

Source DB:  PubMed          Journal:  Medchemcomm        ISSN： 2040-2503            Impact factor:   3.597


  110 in total

1.  Kinetic and mutagenic characterization of the chromosomally encoded Salmonella enterica AAC(6')-Iy aminoglycoside N-acetyltransferase.

Authors:  S Magnet; T Lambert; P Courvalin; J S Blanchard
Journal:  Biochemistry       Date:  2001-03-27       Impact factor: 3.162

2.  Broad-spectrum peptide inhibitors of aminoglycoside antibiotic resistance enzymes.

Authors:  David D Boehr; Kari-ann Draker; Kalinka Koteva; Manjeet Bains; Robert E Hancock; Gerard D Wright
Journal:  Chem Biol       Date:  2003-02

3.  Aminoglycoside microarrays to study antibiotic resistance.

Authors:  Matthew D Disney; Sophie Magnet; John S Blanchard; Peter H Seeberger
Journal:  Angew Chem Int Ed Engl       Date:  2004-03-12       Impact factor: 15.336

4.  The use of neamine as a molecular template: inactivation of bacterial antibiotic resistance enzyme aminoglycoside 3'-phosphotransferase type IIa.

Authors:  J Roestamadji; S Mobashery
Journal:  Bioorg Med Chem Lett       Date:  1998-12-15       Impact factor: 2.823

5.  Molecular mechanisms of antibiotic resistance.

Authors:  Gerard D Wright
Journal:  Chem Commun (Camb)       Date:  2011-02-01       Impact factor: 6.222

6.  Synthesis of a tight-binding, multisubstrate analog inhibitor of gentamicin acetyltransferase I.

Authors:  J W Williams; D B Northrop
Journal:  J Antibiot (Tokyo)       Date:  1979-11       Impact factor: 2.649

7.  Tight binding inhibitors of N-acyl amino sugar and N-acyl amino acid deacetylases.

Authors:  Chengfu Xu; Richard Hall; Jennifer Cummings; Frank M Raushel
Journal:  J Am Chem Soc       Date:  2006-04-05       Impact factor: 15.419

8.  Crystallization and preliminary crystallographic analysis of 3'-aminoglycoside kinase type IIIa complexed with a eukaryotic protein kinase inhibitor, CKI-7.

Authors:  Desiree H Fong; Albert M Berghuis
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2004-09-23

9.  Design and synthesis of tetrahedral intermediate analogues as potential dihydroorotase inhibitors.

Authors:  C H Levenson; R B Meyer
Journal:  J Med Chem       Date:  1984-02       Impact factor: 7.446

10.  Plasmid-mediated high-level resistance to aminoglycosides in Enterobacteriaceae due to 16S rRNA methylation.

Authors:  Marc Galimand; Patrice Courvalin; Thierry Lambert
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191
View more
  4 in total

Review 1.  Amikacin: Uses, Resistance, and Prospects for Inhibition.

Authors:  Maria S Ramirez; Marcelo E Tolmasky
Journal:  Molecules       Date:  2017-12-19       Impact factor: 4.411

2.  Restoration of susceptibility to amikacin by 8-hydroxyquinoline analogs complexed to zinc.

Authors:  Jesus Magallon; Kevin Chiem; Tung Tran; Maria S Ramirez; Veronica Jimenez; Marcelo E Tolmasky
Journal:  PLoS One       Date:  2019-05-29       Impact factor: 3.240

3.  Molecular identification of fluoroquinolone resistance in Salmonella spp. isolated from broiler farms and human samples obtained from two regions in Colombia.

Authors:  María Paula Herrera-Sánchez; Rafael Enrique Castro-Vargas; Luz Clemencia Fandiño-de-Rubio; Roy Rodríguez-Hernández; Iang Schroniltgen Rondón-Barragán
Journal:  Vet World       Date:  2021-07-07

4.  Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Escherichia coli Recovered from Feedlot Beef Cattle in Australia.

Authors:  Yohannes E Messele; Mauida Alkhallawi; Tania Veltman; Darren J Trott; Joe P McMeniman; Stephen P Kidd; Wai Y Low; Kiro R Petrovski
Journal:  Animals (Basel)       Date:  2022-08-31       Impact factor: 3.231
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.