Literature DB >> 2315699

Deciphering the message in protein sequences: tolerance to amino acid substitutions.

J U Bowie1, J F Reidhaar-Olson, W A Lim, R T Sauer.   

Abstract

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of different sequences with similar messages can reveal key features of the code and improve understanding of how a protein folds and how it performs its function.

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Year:  1990        PMID： 2315699     DOI： 10.1126/science.2315699

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  121 in total

1.  Modeling evolutionary landscapes: mutational stability, topology, and superfunnels in sequence space.

Authors:  E Bornberg-Bauer; H S Chan
Journal:  Proc Natl Acad Sci U S A       Date:  1999-09-14       Impact factor: 11.205

Review 2.  The hydrogen exchange core and protein folding.

Authors:  R Li; C Woodward
Journal:  Protein Sci       Date:  1999-08       Impact factor: 6.725

3.  Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species.

Authors:  P J Haney; J H Badger; G L Buldak; C I Reich; C R Woese; G J Olsen
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-30       Impact factor: 11.205

4.  Structure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein design.

Authors:  P Strop; A M Marinescu; S L Mayo
Journal:  Protein Sci       Date:  2000-07       Impact factor: 6.725

5.  Prediction of amino acid sequence from structure.

Authors:  K Raha; A M Wollacott; M J Italia; J R Desjarlais
Journal:  Protein Sci       Date:  2000-06       Impact factor: 6.725

6.  Persistently conserved positions in structurally similar, sequence dissimilar proteins: roles in preserving protein fold and function.

Authors:  Iddo Friedberg; Hanah Margalit
Journal:  Protein Sci       Date:  2002-02       Impact factor: 6.725

7.  Combinatorial mutagenesis to restrict amino acid usage in an enzyme to a reduced set.

Authors:  Satoshi Akanuma; Takanori Kigawa; Shigeyuki Yokoyama
Journal:  Proc Natl Acad Sci U S A       Date:  2002-10-02       Impact factor: 11.205

8.  Electrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments.

Authors:  Deanna Dahlke Ojennus; Sarah E Lehto; Deborah S Wuttke
Journal:  Protein Sci       Date:  2003-01       Impact factor: 6.725

9.  Stably folded de novo proteins from a designed combinatorial library.

Authors:  Yinan Wei; Tun Liu; Stephen L Sazinsky; David A Moffet; István Pelczer; Michael H Hecht
Journal:  Protein Sci       Date:  2003-01       Impact factor: 6.725

10.  Connections between RNA splicing and DNA intron mobility in yeast mitochondria: RNA maturase and DNA endonuclease switching experiments.

Authors:  V Goguel; A Delahodde; C Jacq
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272
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