Literature DB >> 10471592

In vitro activities of strychnos alkaloids and extracts against Plasmodium falciparum.

M Frederich1, M P Hayette, M Tits, P De Mol, L Angenot.   

Abstract

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.

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Year:  1999        PMID： 10471592      PMCID： PMC89474     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

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Journal:  J Pharm Belg       Date:  1951 May-Jun

2.  Alkaloids of Strychnos usambarensis Stem Bark.

Authors:  J Quetin-Leclercq; M Tits; L Angenot; N G Bisset
Journal:  Planta Med       Date:  1991-10       Impact factor: 3.352

3.  Screening of cytotoxic activities of Strychnos alkaloids (methods and results).

Authors:  J Leclercq; M C De Pauw-Gillet; R Bassleer; L Angenot
Journal:  J Ethnopharmacol       Date:  1986-03       Impact factor: 4.360

4.  10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis.

Authors:  M Frédérich; M Tits; M P Hayette; V Brandt; J Penelle; P DeMol; G Llabrès; L Angenot
Journal:  J Nat Prod       Date:  1999-04       Impact factor: 4.050

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Journal:  J Pharm Belg       Date:  1978 Jan-Feb

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Authors:  L Angenot; M Tits
Journal:  Planta Med       Date:  1981-03       Impact factor: 3.352

7.  In vitro cytotoxic activity of two potential anticancer drugs isolated from Strychnos: strychnopentamine and usambarensine.

Authors:  K A Bonjean; M C De Pauw-Gillet; J Quetin-Leclercq; L Angenot; R J Bassleer
Journal:  Anticancer Res       Date:  1996 May-Jun       Impact factor: 2.480

8.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

9.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

10.  The isolation of Nb-methyl-antirhine, malindine and isomalindine from Strychnos usambarensis.

Authors:  M Caprasse; D Tavernier; M J Anteunis; L Angenot
Journal:  Planta Med       Date:  1984-02       Impact factor: 3.352
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  7 in total

1.  In vitro antiplasmodial properties of Flacourtia flavescens Willd. (Flacourtiaceae) and Rytigynia canthioides (Benth.) Robyns (Rubiaceae).

Authors:  Micheline Agassounon Djikpo-Tchibozo; Simplice D Karou; Souleymane Sanon; Fatiou Toukourou; Comlan de Souza
Journal:  Afr J Tradit Complement Altern Med       Date:  2010-10-02

2.  Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells.

Authors:  Giuliana Castello Coatti; Juliana Cristina Marcarini; Daniele Sartori; Queli Cristina Fidelis; Dalva Trevisan Ferreira; Mário Sérgio Mantovani
Journal:  Cytotechnology       Date:  2015-04-17       Impact factor: 2.058

3.  In vivo antimalarial activity of crude extracts and solvent fractions of leaves of Strychnos mitis in Plasmodium berghei infected mice.

Authors:  Selamawit Fentahun; Eyasu Makonnen; Tesfaye Awas; Mirutse Giday
Journal:  BMC Complement Altern Med       Date:  2017-01-05       Impact factor: 3.659

4.  Cinchona alkaloids as natural fetal hemoglobin inducing agents in human erythroleukemia cells.

Authors:  Fizza Iftikhar; Hamad Ali; Syed Ghulam Musharraf
Journal:  RSC Adv       Date:  2019-06-04       Impact factor: 4.036

5.  Unveiling antiplasmodial alkaloids from a cumulative collection of Strychnos extracts by multi-informative molecular networks.

Authors:  Olivier Bonnet; Mehdi A Beniddir; Pierre Champy; Gilles Degotte; Lúcia Mamede; Pauline Desdemoustier; Allison Ledoux; Alembert Tiabou Tchinda; Luc Angenot; Michel Frédérich
Journal:  Front Mol Biosci       Date:  2022-09-26

6.  Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts.

Authors:  Tamara Regina Calvo; Cássia Regina Primila Cardoso; Adriana Candido da Silva Moura; Lourdes Campaner Dos Santos; Ilce Mara Syllos Colus; Wagner Vilegas; Eliana Aparecida Varanda
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-17       Impact factor: 2.629

7.  Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity.

Authors:  Paula Sousa Lage; Pedro Henrique Rocha de Andrade; Amanda de Santana Lopes; Miguel Angel Chávez Fumagalli; Diogo Garcia Valadares; Mariana Costa Duarte; Daniela Pagliara Lage; Lourena Emanuele Costa; Vivian Tamietti Martins; Tatiana Gomes Ribeiro; José Dias de Souza Filho; Carlos Alberto Pereira Tavares; Rodrigo Maia de Pádua; João Paulo Viana Leite; Eduardo Antonio Ferraz Coelho
Journal:  Evid Based Complement Alternat Med       Date:  2013-09-30       Impact factor: 2.629
  7 in total

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