Literature DB >> 3724211

Screening of cytotoxic activities of Strychnos alkaloids (methods and results).

J Leclercq, M C De Pauw-Gillet, R Bassleer, L Angenot.   

Abstract

The potential cytotoxic activities of 46 alkaloids isolated from different Strychnos species were tested on different cancer or normal cells cultured in vitro. The authors used a relatively simple microtest which gives good reproducibility. Most of the active compounds belong to the usambarane skeleton but other structure-activity relationships are being discussed.

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Year:  1986        PMID： 3724211     DOI： 10.1016/0378-8741(86)90169-8

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  6 in total

1.  Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4'-pyrano[2,3-c]pyrazole] system.

Authors:  Michail N Elinson; Alexander S Dorofeev; Fedor M Miloserdov; Gennady I Nikishin
Journal:  Mol Divers       Date:  2008-12-02       Impact factor: 2.943

Review 2.  In vitro activities of strychnos alkaloids and extracts against Plasmodium falciparum.

Authors:  M Frederich; M P Hayette; M Tits; P De Mol; L Angenot
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

3.  Total synthesis of (±)-coerulescine and (±)-horsfiline.

Authors:  Mukund G Kulkarni; Attrimuni P Dhondge; Sanjay W Chavhan; Ajit S Borhade; Yunnus B Shaikh; Deekshaputra R Birhade; Mayur P Desai; Nagorao R Dhatrak
Journal:  Beilstein J Org Chem       Date:  2010-09-27       Impact factor: 2.883

4.  Electrochemically induced multicomponent assembling of isatins, 4-hydroxyquinolin-2(1H)-one and malononitrile: a convenient and efficient way to functionalized spirocyclic [indole-3,4'-pyrano[3,2-c]quinoline] scaffold.

Authors:  Michail N Elinson; Valentina M Merkulova; Alexey I Ilovaisky; Dmitry V Demchuk; Pavel A Belyakov; Gennady I Nikishin
Journal:  Mol Divers       Date:  2009-11-17       Impact factor: 2.943

Review 5.  Application of the Asymmetric Pictet-Spengler Reaction in the Total Synthesis of Natural Products and Relevant Biologically Active Compounds.

Authors:  Majid M Heravi; Vahideh Zadsirjan; Masumeh Malmir
Journal:  Molecules       Date:  2018-04-18       Impact factor: 4.411

6.  Green synthesis of new pyrrolidine-fused spirooxindoles via three-component domino reaction in EtOH/H2O.

Authors:  Yong-Chao Wang; Jun-Liang Wang; Kevin S Burgess; Jiang-Wei Zhang; Qiu-Mei Zheng; Ya-Dan Pu; Li-Jun Yan; Xue-Bing Chen
Journal:  RSC Adv       Date:  2018-02-02       Impact factor: 4.036
  6 in total

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