Literature DB >> 10217724

10'-Hydroxyusambarensine, a new antimalarial bisindole alkaloid from the roots of Strychnos usambarensis.

M Frédérich1, M Tits, M P Hayette, V Brandt, J Penelle, P DeMol, G Llabrès, L Angenot.   

Abstract

Reinvestigation of Strychnos usambarensis Gilg resulted in the isolation of a tertiary phenolic bisindole alkaloid, 10'-hydroxyusambarensine (1), which was identified by detailed spectroscopic methods. Compound 1 was moderately active against two strains of Plasmodium falciparum in vitro.

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Year:  1999        PMID： 10217724     DOI： 10.1021/np980375m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

Review 1.  In vitro activities of strychnos alkaloids and extracts against Plasmodium falciparum.

Authors:  M Frederich; M P Hayette; M Tits; P De Mol; L Angenot
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

Review 2.  A review on potential of natural products in the management of COVID-19.

Authors:  Rudra Chakravarti; Rajveer Singh; Arijit Ghosh; Dhritiman Dey; Priyanka Sharma; Ravichandiran Velayutham; Syamal Roy; Dipanjan Ghosh
Journal:  RSC Adv       Date:  2021-05-12       Impact factor: 4.036

Review 3.  The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.

Authors:  Pascal Amoa Onguéné; Fidele Ntie-Kang; Lydia Likowo Lifongo; Jean Claude Ndom; Wolfgang Sippl; Luc Meva'a Mbaze
Journal:  Malar J       Date:  2013-12-13       Impact factor: 2.979

4.  African derived phytocompounds may interfere with SARS-CoV-2 RNA capping machinery via inhibition of 2'-O-ribose methyltransferase: An in silico perspective.

Authors:  Gideon A Gyebi; Oludare M Ogunyemi; Adedotun A Adefolalu; Alejandro Rodríguez-Martínez; Juan F López-Pastor; Antonio J Banegas-Luna; Horacio Pérez-Sánchez; Adegbenro P Adegunloye; Olalekan B Ogunro; Saheed O Afolabi
Journal:  J Mol Struct       Date:  2022-04-12       Impact factor: 3.841
  4 in total

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