Literature DB >> 10449738

The speed limit for protein folding measured by triplet-triplet energy transfer.

O Bieri1, J Wirz, B Hellrung, M Schutkowski, M Drewello, T Kiefhaber.   

Abstract

A direct measure of intramolecular chain diffusion is obtained by the determination of triplet-triplet energy-transfer rates between a donor and an acceptor chromophore attached at defined points on a polypeptide chain. Single exponential kinetics of contact formation are observed on the nanosecond time scale for polypeptides in which donor and acceptor are linked by repeating units of glycine and serine residues. The rates depend on the number of peptide bonds (N) separating donor and acceptor and show a maximum for the shortest peptides (N = 3) with a time constant (tau = 1/k) of 20 ns. This sets an upper limit for the speed of formation of the first side-chain contacts during protein folding.

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Year:  1999        PMID： 10449738      PMCID： PMC22254          DOI： 10.1073/pnas.96.17.9597

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  15 in total

1.  Characterization of transient intermediates in lysozyme folding with time-resolved small-angle X-ray scattering.

Authors:  D J Segel; A Bachmann; J Hofrichter; K O Hodgson; S Doniach; T Kiefhaber
Journal:  J Mol Biol       Date:  1999-05-07       Impact factor: 5.469

2.  Kinetic analysis of folding and unfolding the 56 amino acid IgG-binding domain of streptococcal protein G.

Authors:  P Alexander; J Orban; P Bryan
Journal:  Biochemistry       Date:  1992-08-18       Impact factor: 3.162

3.  Folding of chymotrypsin inhibitor 2. 1. Evidence for a two-state transition.

Authors:  S E Jackson; A R Fersht
Journal:  Biochemistry       Date:  1991-10-29       Impact factor: 3.162

4.  Theoretical predictions of folding pathways by using the proximity rule, with applications to bovine pancreatic trypsin inhibitor.

Authors:  C J Camacho; D Thirumalai
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

5.  Diffusion-limited contact formation in unfolded cytochrome c: estimating the maximum rate of protein folding.

Authors:  S J Hagen; J Hofrichter; A Szabo; W A Eaton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

Review 6.  The molten globule state as a clue for understanding the folding and cooperativity of globular-protein structure.

Authors:  K Kuwajima
Journal:  Proteins       Date:  1989

7.  Analysis and prediction of the different types of beta-turn in proteins.

Authors:  C M Wilmot; J M Thornton
Journal:  J Mol Biol       Date:  1988-09-05       Impact factor: 5.469

8.  Brownian dynamics of chain polymers.

Authors:  M Fixman
Journal:  Faraday Discuss Chem Soc       Date:  1987

9.  Extremely rapid protein folding in the absence of intermediates.

Authors:  T Schindler; M Herrler; M A Marahiel; F X Schmid
Journal:  Nat Struct Biol       Date:  1995-08

10.  Proteins in 6-M guanidine hydrochloride. Demonstration of random coil behavior.

Authors:  C Tanford; K Kawahara; S Lapanje
Journal:  J Biol Chem       Date:  1966-04-25       Impact factor: 5.157
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  86 in total

1.  Non-Arrhenius kinetics for the loop closure of a DNA hairpin.

Authors:  M I Wallace; L Ying; S Balasubramanian; D Klenerman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-24       Impact factor: 11.205

2.  Protein folding and unfolding in microseconds to nanoseconds by experiment and simulation.

Authors:  U Mayor; C M Johnson; V Daggett; A R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

3.  How the folding rate constant of simple, single-domain proteins depends on the number of native contacts.

Authors:  Dmitrii E Makarov; Craig A Keller; Kevin W Plaxco; Horia Metiu
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

4.  Fluorescence correlation spectroscopy of fast chain dynamics within denatured protein L.

Authors:  Eilon Sherman; Gilad Haran
Journal:  Chemphyschem       Date:  2011-01-26       Impact factor: 3.102

5.  Ultrafast spectroscopy reveals subnanosecond peptide conformational dynamics and validates molecular dynamics simulation.

Authors:  Sebastian Spörlein; Heiko Carstens; Helmut Satzger; Christian Renner; Raymond Behrendt; Luis Moroder; Paul Tavan; Wolfgang Zinth; Josef Wachtveitl
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-11       Impact factor: 11.205

6.  The dual role of a loop with low loop contact distance in folding and domain swapping.

Authors:  Apichart Linhananta; Hongyi Zhou; Yaoqi Zhou
Journal:  Protein Sci       Date:  2002-07       Impact factor: 6.725

7.  Picosecond conformational transition and equilibration of a cyclic peptide.

Authors:  Jens Bredenbeck; Jan Helbing; Arne Sieg; Tobias Schrader; Wolfgang Zinth; Christian Renner; Raymond Behrendt; Luis Moroder; Josef Wachtveitl; Peter Hamm
Journal:  Proc Natl Acad Sci U S A       Date:  2003-05-07       Impact factor: 11.205

8.  Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein.

Authors:  Yongjin Zhu; Darwin O V Alonso; Kosuke Maki; Cheng-Yen Huang; Steven J Lahr; Valerie Daggett; Heinrich Roder; William F DeGrado; Feng Gai
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-11       Impact factor: 11.205

Review 9.  The topomer search model: A simple, quantitative theory of two-state protein folding kinetics.

Authors:  Dmitrii E Makarov; Kevin W Plaxco
Journal:  Protein Sci       Date:  2003-01       Impact factor: 6.725

10.  The protein-folding speed limit: intrachain diffusion times set by electron-transfer rates in denatured Ru(NH3)5(His-33)-Zn-cytochrome c.

Authors:  I-Jy Chang; Jennifer C Lee; Jay R Winkler; Harry B Gray
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-19       Impact factor: 11.205
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