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Literature DB >> 10419969

Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.

Abstract

MarR negatively regulates expression of the multiple antibiotic resistance operon (marRAB) in Escherichia coli. In this study, it was demonstrated that sodium salicylate, plumbagin, 2, 4-dinitrophenol, and menadione-inducers of the marRAB operon in whole cells-all interfered with the repressor activity of MarR in vitro. It is proposed that these compounds can interact directly with MarR to affect its repressor activity.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10419969 PMCID： PMC103602

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

30 in total

1. Molecular basis of triclosan activity.

Authors: C W Levy; A Roujeinikova; S Sedelnikova; P J Baker; A R Stuitje; A R Slabas; D W Rice; J B Rafferty
Journal: Nature Date: 1999-04-01 Impact factor: 49.962

2. Characterization of MarR superrepressor mutants.

Authors: M N Alekshun; S B Levy
Journal: J Bacteriol Date: 1999-05 Impact factor: 3.490

3. Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr.

Authors: P N Markham; J LoGuidice; A A Neyfakh
Journal: Biochem Biophys Res Commun Date: 1997-10-09 Impact factor: 3.575

4. Triclosan targets lipid synthesis.

Authors: L M McMurry; M Oethinger; S B Levy
Journal: Nature Date: 1998-08-06 Impact factor: 49.962

5. Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci.

Authors: M C Moken; L M McMurry; S B Levy
Journal: Antimicrob Agents Chemother Date: 1997-12 Impact factor: 5.191

Review 6. Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

Authors: M N Alekshun; S B Levy
Journal: Antimicrob Agents Chemother Date: 1997-10 Impact factor: 5.191

7. Multidrug resistance following expression of the Escherichia coli marA gene in Mycobacterium smegmatis.

Authors: P F McDermott; D G White; I Podglajen; M N Alekshun; S B Levy
Journal: J Bacteriol Date: 1998-06 Impact factor: 3.490

8. Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter.

Authors: E E Zheleznova; P N Markham; A A Neyfakh; R G Brennan
Journal: Cell Date: 1999-02-05 Impact factor: 41.582

9. Multidrug efflux pump AcrAB of Salmonella typhimurium excretes only those beta-lactam antibiotics containing lipophilic side chains.

Authors: H Nikaido; M Basina; V Nguyen; E Y Rosenberg
Journal: J Bacteriol Date: 1998-09 Impact factor: 3.490

10. Purification and characterization of trp aporepressor.

Authors: A Joachimiak; R L Kelley; R P Gunsalus; C Yanofsky; P B Sigler
Journal: Proc Natl Acad Sci U S A Date: 1983-02 Impact factor: 11.205

76 in total

1. Characterization of MarR superrepressor mutants.

Authors: M N Alekshun; S B Levy
Journal: J Bacteriol Date: 1999-05 Impact factor: 3.490

2. Modification of outer membrane protein profile and evidence suggesting an active drug pump in Enterobacter aerogenes clinical strains.

Authors: Stéphane Gayet; Renaud Chollet; Gérard Molle; Jean-Marie Pagès; Jacqueline Chevalier
Journal: Antimicrob Agents Chemother Date: 2003-05 Impact factor: 5.191

3. The cyclic dipeptide cyclo(Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae.

Authors: Xiaowen R Bina; James E Bina
Journal: J Bacteriol Date: 2010-05-07 Impact factor: 3.490

4. Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.

Authors: C Balagué; E G Véscovi
Journal: Antimicrob Agents Chemother Date: 2001-06 Impact factor: 5.191

5. Toxic waste disposal in Escherichia coli.

Authors: Robert B Helling; Brian K Janes; Heather Kimball; Timothy Tran; Michael Bundesmann; Pietra Check; Darcy Phelan; Charles Miller
Journal: J Bacteriol Date: 2002-07 Impact factor: 3.490

6. The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli.

Authors: Xiaowen Bina; Vincent Perreten; Stuart B Levy
Journal: J Bacteriol Date: 2003-02 Impact factor: 3.490

7. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate.

Authors: Natalya Baranova; Hiroshi Nikaido
Journal: J Bacteriol Date: 2002-08 Impact factor: 3.490

8. Transcriptional cross talk within the mar-sox-rob regulon in Escherichia coli is limited to the rob and marRAB operons.

Authors: Lon M Chubiz; George D Glekas; Christopher V Rao
Journal: J Bacteriol Date: 2012-06-29 Impact factor: 3.490

9. Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.

Authors: Lon M Chubiz; Christopher V Rao
Journal: J Bacteriol Date: 2010-07-16 Impact factor: 3.490

10. LVIS553 transcriptional regulator specifically recognizes novobiocin as an effector molecule.

Authors: Fernando A Pagliai; Christopher L Gardner; Santosh G Pande; Graciela L Lorca
Journal: J Biol Chem Date: 2010-03-22 Impact factor: 5.157