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Literature DB >> 12057966

Toxic waste disposal in Escherichia coli.

Robert B Helling¹, Brian K Janes, Heather Kimball, Timothy Tran, Michael Bundesmann, Pietra Check, Darcy Phelan, Charles Miller.

Abstract

About 10% of the nalidixic acid-resistant (Nal(r)) mutants in a transposition-induced library exhibited a growth factor requirement as the result of cysH, icdA, metE, or purB mutation. Resistance in all of these mutants required a functional AcrAB-TolC efflux pump, but the EmrAB-TolC pump played no obvious role. Transcription of acrAB was increased in each type of Nal(r) mutant. In the icdA and purB mutants, each of the known signaling pathways appeared to be used in activating the AcrAB-TolC pump. The metabolites that accumulate upstream of the blocks caused by the mutations are hypothesized to increase the levels of the AcrAB-TolC pump, thereby removing nalidixic acid from the organism.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2002 PMID： 12057966 PMCID： PMC135154 DOI： 10.1128/JB.184.13.3699-3703.2002

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

38 in total

1. Structural mechanisms of QacR induction and multidrug recognition.

Authors: M A Schumacher; M C Miller; S Grkovic; M H Brown; R A Skurray; R G Brennan
Journal: Science Date: 2001-12-07 Impact factor: 47.728

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Journal: J Bacteriol Date: 1950-07 Impact factor: 3.490

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Journal: Microbiology (Reading) Date: 1998-04 Impact factor: 2.777

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Authors: R R Ariza; Z Li; N Ringstad; B Demple
Journal: J Bacteriol Date: 1995-04 Impact factor: 3.490

5. Insertion, excision, and inversion of Tn5.

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Journal: Cold Spring Harb Symp Quant Biol Date: 1981

6. Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12.

Authors: R Aono; N Tsukagoshi; M Yamamoto
Journal: J Bacteriol Date: 1998-02 Impact factor: 3.490

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Journal: Mol Microbiol Date: 1996-01 Impact factor: 3.501

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Authors: O Lomovskaya; K Lewis
Journal: Proc Natl Acad Sci U S A Date: 1992-10-01 Impact factor: 11.205

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Authors: M Gellert; K Mizuuchi; M H O'Dea; T Itoh; J I Tomizawa
Journal: Proc Natl Acad Sci U S A Date: 1977-11 Impact factor: 11.205

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Authors: D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal: Mol Microbiol Date: 1995-04 Impact factor: 3.501

34 in total

1. Aromatic acid metabolites of Escherichia coli K-12 can induce the marRAB operon.

Authors: Lon M Chubiz; Christopher V Rao
Journal: J Bacteriol Date: 2010-07-16 Impact factor: 3.490

Review 2. Vacuuming the periplasm.

Authors: Olga Lomovskaya; Maxim Totrov
Journal: J Bacteriol Date: 2005-03 Impact factor: 3.490

3. An excretory function for the Escherichia coli outer membrane pore TolC: upregulation of marA and soxS transcription and Rob activity due to metabolites accumulated in tolC mutants.

Authors: Judah L Rosner; Robert G Martin
Journal: J Bacteriol Date: 2009-06-05 Impact factor: 3.490

Review 4. The TetR family of regulators.

Authors: Leslie Cuthbertson; Justin R Nodwell
Journal: Microbiol Mol Biol Rev Date: 2013-09 Impact factor: 11.056

5. Regulation of acrAB expression by cellular metabolites in Escherichia coli.

Authors: Cristian Ruiz; Stuart B Levy
Journal: J Antimicrob Chemother Date: 2013-09-15 Impact factor: 5.790

6. Crystal structure of the multidrug efflux transporter AcrB at 3.1A resolution reveals the N-terminal region with conserved amino acids.

Authors: Debanu Das; Qian Steven Xu; Jonas Y Lee; Irina Ankoudinova; Candice Huang; Yun Lou; Andy DeGiovanni; Rosalind Kim; Sung-Hou Kim
Journal: J Struct Biol Date: 2006-12-24 Impact factor: 2.867