Literature DB >> 10322039

Characterization of MarR superrepressor mutants.

M N Alekshun1, S B Levy.   

Abstract

MarR negatively regulates expression of the multiple antibiotic resistance (mar) locus in Escherichia coli. Superrepressor mutants, generated in order to study regions of MarR required for function, exhibited altered inducer recognition properties in whole cells and increased DNA binding to marO in vitro. Mutations occurred in three areas of the relatively small MarR protein (144 amino acids). It is surmised that superrepression results from increased DNA binding activities of these mutant proteins.

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Year:  1999        PMID： 10322039      PMCID： PMC93793     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.

Authors:  M N Alekshun; S B Levy
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

2.  Origins of DNA-binding specificity: role of protein contacts with the DNA backbone.

Authors:  J F Schildbach; A W Karzai; B E Raumann; R T Sauer
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205

Review 3.  Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon.

Authors:  M N Alekshun; S B Levy
Journal:  Antimicrob Agents Chemother       Date:  1997-10       Impact factor: 5.191

4.  The tpl promoter of Citrobacter freundii is activated by the TyrR protein.

Authors:  H Q Smith; R L Somerville
Journal:  J Bacteriol       Date:  1997-09       Impact factor: 3.490

5.  trp repressor mutations alter DNA complex stoichiometry.

Authors:  Y C Liu; K S Matthews
Journal:  J Biol Chem       Date:  1994-01-21       Impact factor: 5.157

6.  Positive-selection vectors using the F plasmid ccdB killer gene.

Authors:  P Bernard; P Gabant; E M Bahassi; M Couturier
Journal:  Gene       Date:  1994-10-11       Impact factor: 3.688

7.  Isolation of an oxygen-sensitive FNR protein of Escherichia coli: interaction at activator and repressor sites of FNR-controlled genes.

Authors:  S B Melville; R P Gunsalus
Journal:  Proc Natl Acad Sci U S A       Date:  1996-02-06       Impact factor: 11.205

8.  Purification and characterization of trp aporepressor.

Authors:  A Joachimiak; R L Kelley; R P Gunsalus; C Yanofsky; P B Sigler
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

9.  Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracycline.

Authors:  A M George; S B Levy
Journal:  J Bacteriol       Date:  1983-08       Impact factor: 3.490

10.  Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.

Authors:  R G Martin; J L Rosner
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-06       Impact factor: 11.205
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  14 in total

1.  Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro.

Authors:  M N Alekshun; S B Levy
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

2.  Activation of multiple antibiotic resistance in uropathogenic Escherichia coli strains by aryloxoalcanoic acid compounds.

Authors:  C Balagué; E G Véscovi
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

3.  The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli.

Authors:  Xiaowen Bina; Vincent Perreten; Stuart B Levy
Journal:  J Bacteriol       Date:  2003-02       Impact factor: 3.490

4.  Amino acid residues involved in inactivation of the Escherichia coli multidrug resistance repressor MarR by salicylate, 2,4-dinitrophenol, and plumbagin.

Authors:  Laura M McMurry; Stuart B Levy
Journal:  FEMS Microbiol Lett       Date:  2013-10-21       Impact factor: 2.742

5.  Identification and functional characterization of CbaR, a MarR-like modulator of the cbaABC-encoded chlorobenzoate catabolism pathway.

Authors:  M A Providenti; R C Wyndham
Journal:  Appl Environ Microbiol       Date:  2001-08       Impact factor: 4.792

6.  Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator.

Authors:  Daiana A Capdevila; Fidel Huerta; Katherine A Edmonds; My Tra Le; Hongwei Wu; David P Giedroc
Journal:  Elife       Date:  2018-10-17       Impact factor: 8.140

7.  GyrA interacts with MarR to reduce repression of the marRAB operon in Escherichia coli.

Authors:  Francis Domain; Stuart B Levy
Journal:  J Bacteriol       Date:  2009-11-20       Impact factor: 3.490

8.  Involvement of MarR and YedS in carbapenem resistance in a clinical isolate of Escherichia coli from China.

Authors:  Douglas M Warner; Qiwen Yang; Valérie Duval; Minjun Chen; Yingchun Xu; Stuart B Levy
Journal:  Antimicrob Agents Chemother       Date:  2013-01-14       Impact factor: 5.191

9.  High incidence of multiple antibiotic resistant cells in cultures of in enterohemorrhagic Escherichia coli O157:H7.

Authors:  Benjamin R Carone; Tao Xu; Kenan C Murphy; Martin G Marinus
Journal:  Mutat Res       Date:  2013-12-18       Impact factor: 2.433

10.  Mutational analysis of the multiple-antibiotic resistance regulator MarR reveals a ligand binding pocket at the interface between the dimerization and DNA binding domains.

Authors:  Valérie Duval; Laura M McMurry; Kimberly Foster; James F Head; Stuart B Levy
Journal:  J Bacteriol       Date:  2013-05-17       Impact factor: 3.490
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