Literature DB >> 20453095

The cyclic dipeptide cyclo(Phe-Pro) inhibits cholera toxin and toxin-coregulated pilus production in O1 El Tor Vibrio cholerae.

Xiaowen R Bina1, James E Bina.   

Abstract

Cyclo(Phe-Pro) is a cyclic dipeptide produced by multiple Vibrio species. In this work, we present evidence that cyclo(Phe-Pro) inhibits the production of the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) in O1 El Tor Vibrio cholerae strain N16961 during growth under virulence gene-inducing conditions. The cyclo(Phe-Pro) inhibition of CT and TCP production correlated with reduced transcription of the virulence regulator tcpPH and was alleviated by overexpression of tcpPH.

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Year:  2010        PMID： 20453095      PMCID： PMC2897329          DOI： 10.1128/JB.00191-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

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Authors:  V J DiRita; C Parsot; G Jander; J J Mekalanos
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Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-27       Impact factor: 11.205

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Authors:  G Kovacikova; K Skorupski
Journal:  J Bacteriol       Date:  1999-07       Impact factor: 3.490

7.  TcpP protein is a positive regulator of virulence gene expression in Vibrio cholerae.

Authors:  C C Häse; J J Mekalanos
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8.  A new level in the Vibrio cholerae ToxR virulence cascade: AphA is required for transcriptional activation of the tcpPH operon.

Authors:  K Skorupski; R K Taylor
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9.  The virulence gene activator ToxT from Vibrio cholerae is a member of the AraC family of transcriptional activators.

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  16 in total

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Authors:  Vanessa M Ante; X Renee Bina; James E Bina
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Authors:  D E Kunkle; X R Bina; J E Bina
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7.  Cyclo(valine-valine) inhibits Vibrio cholerae virulence gene expression.

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8.  Vibrio cholerae VexH encodes a multiple drug efflux pump that contributes to the production of cholera toxin and the toxin co-regulated pilus.

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9.  Vibrio cholerae TolC Is Required for Expression of the ToxR Regulon.

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10.  Cyclo(phenylalanine-proline) induces DNA damage in mammalian cells via reactive oxygen species.

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