| Literature DB >> 10411480 |
H S Kim1, Y Shibata, Y Wataya, K Tsuchiya, A Masuyama, M Nojima.
Abstract
A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.Entities:
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Year: 1999 PMID： 10411480 DOI： 10.1021/jm990014j
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446