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Literature DB >> 17485500

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Yuxiang Dong¹, Darren Creek, Jacques Chollet, Hugues Matile, Susan A Charman, Sergio Wittlin, James K Wood, Jonathan L Vennerstrom.

Abstract

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron(II)-mediated activation.

Entities: Chemical Species

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Year: 2007 PMID： 17485500 PMCID： PMC1932524 DOI： 10.1128/AAC.00264-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

Review 1. Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes.

Authors: Yuxiang Dong
Journal: Mini Rev Med Chem Date: 2002-04 Impact factor: 3.862

Review 2. A medicinal chemistry perspective on artemisinin and related endoperoxides.

Authors: Paul M O'Neill; Gary H Posner
Journal: J Med Chem Date: 2004-06-03 Impact factor: 7.446

3. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

Authors: Y Dong; H Matile; J Chollet; R Kaminsky; J K Wood; J L Vennerstrom
Journal: J Med Chem Date: 1999-04-22 Impact factor: 7.446

Review 1. Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.

Authors: Mithun Rudrapal; Dipak Chetia
Journal: Drug Des Devel Ther Date: 2016-11-01 Impact factor: 4.162

1 in total

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers).

Review 1. Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes.

Review 2. A medicinal chemistry perspective on artemisinin and related endoperoxides.

3. Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.

Review 4. Artemisinin: mechanisms of action, resistance and toxicity.

5. Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes.

Review 6. Why artemisinin and certain synthetic peroxides are potent antimalarials. Implications for the mode of action.

7. Mixed steroidal 1,2,4,5-tetraoxanes: antimalarial and antimycobacterial activity.

Review 8. Synthetic peroxides as antimalarials.

9. Dispiro-1,2,4,5-tetraoxanes: a new class of antimalarial peroxides.

10. Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials.

Review 1. Endoperoxide antimalarials: development, structural diversity and pharmacodynamic aspects with reference to 1,2,4-trioxane-based structural scaffold.