Literature DB >> 12783311

In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum.

Khurshida Begum1, Hye-Sook Kim, Veena Kumar, Igor Stojiljkovic, Yusuke Wataya.   

Abstract

The in vitro antimalarial activity against Plasmodium falciparum and heme polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC(50)) ranging from 15.5 microM to 190 microM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12783311     DOI： 10.1007/s00436-003-0830-9

Source DB:  PubMed          Journal:  Parasitol Res        ISSN： 0932-0113            Impact factor:   2.289


  23 in total

Review 1.  Chemotherapy for falciparum malaria: the armoury, the problems and the prospects.

Authors:  P A Winstanley
Journal:  Parasitol Today       Date:  2000-04

2.  Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes.

Authors:  L Ding; J Balzarini; D Schols; B Meunier; E de Clercq
Journal:  Biochem Pharmacol       Date:  1992-10-20       Impact factor: 5.858

Review 3.  Hemoglobin metabolism in the malaria parasite Plasmodium falciparum.

Authors:  S E Francis; D J Sullivan; D E Goldberg
Journal:  Annu Rev Microbiol       Date:  1997       Impact factor: 15.500

4.  Inhibition of hemozoin formation in Plasmodium falciparum trophozoite extracts by heme analogs: possible implication in the resistance to malaria conferred by the beta-thalassemia trait.

Authors:  J A Martiney; A Cerami; A F Slater
Journal:  Mol Med       Date:  1996-03       Impact factor: 6.354

5.  Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasites.

Authors:  A C Chou; R Chevli; C D Fitch
Journal:  Biochemistry       Date:  1980-04-15       Impact factor: 3.162

6.  New type of febrifugine analogues, bearing a quinolizidine moiety, show potent antimalarial activity against Plasmodium malaria parasite.

Authors:  Y Takaya; H Tasaka; T Chiba; K Uwai; M Tanitsu; H S Kim; Y Wataya; M Miura; M Takeshita; Y Oshima
Journal:  J Med Chem       Date:  1999-08-12       Impact factor: 7.446

7.  Synthesis and antimalarial activity of novel medium-sized 1,2,4,5-tetraoxacycloalkanes.

Authors:  H S Kim; Y Nagai; K Ono; K Begum; Y Wataya; Y Hamada; K Tsuchiya; A Masuyama; M Nojima; K J McCullough
Journal:  J Med Chem       Date:  2001-07-05       Impact factor: 7.446

8.  A novel endogenous antimalarial: Fe(II)-protoporphyrin IX alpha (heme) inhibits hematin polymerization to beta-hematin (malaria pigment) and kills malaria parasites.

Authors:  D Monti; B Vodopivec; N Basilico; P Olliaro; D Taramelli
Journal:  Biochemistry       Date:  1999-07-13       Impact factor: 3.162

9.  [Interaction of chloroquine with ferriprotophorphyrin IX. Nuclear magnetic resonance study].

Authors:  S Moreau; B Perly; J Biguet
Journal:  Biochimie       Date:  1982 Nov-Dec       Impact factor: 4.079

10.  Malarial haemozoin/beta-haematin supports haem polymerization in the absence of protein.

Authors:  A Dorn; R Stoffel; H Matile; A Bubendorf; R G Ridley
Journal:  Nature       Date:  1995-03-16       Impact factor: 49.962
View more
  7 in total

1.  Reaction of artemisinin with haemoglobin: implications for antimalarial activity.

Authors:  Rangiah Kannan; Krishan Kumar; Dinkar Sahal; Shrikant Kukreti; Virander S Chauhan
Journal:  Biochem J       Date:  2005-01-15       Impact factor: 3.857

2.  Extracellular heme uptake and the challenges of bacterial cell membranes.

Authors:  Aaron D Smith; Angela Wilks
Journal:  Curr Top Membr       Date:  2012       Impact factor: 3.049

3.  Activation of artemisinin and heme degradation in Leishmania tarentolae promastigotes: A possible link.

Authors:  Gerald Geroldinger; Matthias Tonner; Judith Quirgst; Martin Walter; Sritama De Sarkar; Laura Machín; Lianet Monzote; Klaus Stolze; J Catharina Duvigneau; Katrin Staniek; Mitali Chatterjee; Lars Gille
Journal:  Biochem Pharmacol       Date:  2019-11-29       Impact factor: 5.858

4.  Novel inhibitor cystine knot peptides from Momordica charantia.

Authors:  Wen-Jun He; Lai Yue Chan; Richard J Clark; Jun Tang; Guang-Zhi Zeng; Octavio L Franco; Cinzia Cantacessi; David J Craik; Norelle L Daly; Ning-Hua Tan
Journal:  PLoS One       Date:  2013-10-08       Impact factor: 3.240

Review 5.  Porphyrin Derivative Nanoformulations for Therapy and Antiparasitic Agents.

Authors:  Daiana K Deda; Bernardo A Iglesias; Eduardo Alves; Koiti Araki; Celia R S Garcia
Journal:  Molecules       Date:  2020-04-29       Impact factor: 4.411

Review 6.  Recent Advances in the Biological Investigation of Organometallic Platinum-Group Metal (Ir, Ru, Rh, Os, Pd, Pt) Complexes as Antimalarial Agents.

Authors:  Mziyanda Mbaba; Taryn M Golding; Gregory S Smith
Journal:  Molecules       Date:  2020-11-12       Impact factor: 4.411

Review 7.  The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs.

Authors:  Helenita C Quadros; Mariana C B Silva; Diogo R M Moreira
Journal:  Pharmaceuticals (Basel)       Date:  2022-01-04
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.