Literature DB >> 10385619

Developmental regulation of SR protein phosphorylation and activity.

J R Sanford1, J P Bruzik.   

Abstract

Serine/arginine-rich splicing factors (SR proteins) are substrates for serine phosphorylation that can regulate SR protein function. We have observed gross changes in SR protein phosphorylation during early development coincident with major zygotic gene activation in the nematode Ascaris lumbricoides. These differences correlate with large-scale changes in SR protein activity in promoting both trans- and cis-splicing. Importantly, inactive early stage extracts can be made splicing competent on addition of later stage SR proteins. These data suggest that changes in SR protein phosphorylation have a role in the activation of pre-mRNA splicing during early development.

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Year:  1999        PMID： 10385619      PMCID： PMC316808          DOI： 10.1101/gad.13.12.1513

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  39 in total

1.  Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.

Authors:  W Cao; S F Jamison; M A Garcia-Blanco
Journal:  RNA       Date:  1997-12       Impact factor: 4.942

2.  SR proteins are sufficient for exon bridging across an intron.

Authors:  J M Stark; D P Bazett-Jones; M Herfort; M B Roth
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

3.  Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos.

Authors:  S Bellier; S Chastant; P Adenot; M Vincent; J P Renard; O Bensaude
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

Review 4.  Splicing glue: a role for SR proteins in trans splicing?

Authors:  J P Bruzik
Journal:  Microb Pathog       Date:  1996-09       Impact factor: 3.738

5.  Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins.

Authors:  A Kanopka; O Mühlemann; S Petersen-Mahrt; C Estmer; C Ohrmalm; G Akusjärvi
Journal:  Nature       Date:  1998-05-14       Impact factor: 49.962

6.  Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis.

Authors:  C Wang; K Chua; W Seghezzi; E Lees; O Gozani; R Reed
Journal:  Genes Dev       Date:  1998-05-15       Impact factor: 11.361

Review 7.  RNA polymerase II holoenzyme and transcriptional regulation.

Authors:  J Greenblatt
Journal:  Curr Opin Cell Biol       Date:  1997-06       Impact factor: 8.382

Review 8.  Protein functions in pre-mRNA splicing.

Authors:  C L Will; R Lührmann
Journal:  Curr Opin Cell Biol       Date:  1997-06       Impact factor: 8.382

9.  A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm.

Authors:  J F Cáceres; G R Screaton; A R Krainer
Journal:  Genes Dev       Date:  1998-01-01       Impact factor: 11.361

10.  SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors.

Authors:  K Colwill; L L Feng; J M Yeakley; G D Gish; J F Cáceres; T Pawson; X D Fu
Journal:  J Biol Chem       Date:  1996-10-04       Impact factor: 5.157
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  30 in total

1.  Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

Authors:  D C Barnard; J G Patton
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

2.  Functional selection of splicing enhancers that stimulate trans-splicing in vitro.

Authors:  L A Boukis; J P Bruzik
Journal:  RNA       Date:  2001-06       Impact factor: 4.942

3.  3' splice site recognition in nematode trans-splicing involves enhancer-dependent recruitment of U2 snRNP.

Authors:  C M Romfo; P A Maroney; S Wu; T W Nilsen
Journal:  RNA       Date:  2001-06       Impact factor: 4.942

4.  Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.

Authors:  Y Shav-Tal; M Cohen; S Lapter; B Dye; J G Patton; J Vandekerckhove; D Zipori
Journal:  Mol Biol Cell       Date:  2001-08       Impact factor: 4.138

Review 5.  Sorting out the complexity of SR protein functions.

Authors:  B R Graveley
Journal:  RNA       Date:  2000-09       Impact factor: 4.942

6.  Multiple roles for SR proteins in trans splicing.

Authors:  Suzanne Furuyama; James P Bruzik
Journal:  Mol Cell Biol       Date:  2002-08       Impact factor: 4.272

7.  Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.

Authors:  Y Tang; I Horikawa; M Ajiro; A I Robles; K Fujita; A M Mondal; J K Stauffer; Z-M Zheng; C C Harris
Journal:  Oncogene       Date:  2012-07-09       Impact factor: 9.867

Review 8.  The RNAissance family: SR proteins as multifaceted regulators of gene expression.

Authors:  Jonathan M Howard; Jeremy R Sanford
Journal:  Wiley Interdiscip Rev RNA       Date:  2014-08-22       Impact factor: 9.957

9.  Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.

Authors:  Xiang-Yang Zhong; Jian-Hua Ding; Joseph A Adams; Gourisankar Ghosh; Xiang-Dong Fu
Journal:  Genes Dev       Date:  2009-02-15       Impact factor: 11.361

10.  The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.

Authors:  A N Ladd; N Charlet; T A Cooper
Journal:  Mol Cell Biol       Date:  2001-02       Impact factor: 4.272
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