Literature DB >> 10384714

Synthesis and analgesic activity of some triazoles and triazolothiadiazines.

G Turan-Zitouni1, Z A Kaplancikli, K Erol, F S Kiliç.   

Abstract

The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described. The chemical structure of the compounds were elucidated by analytical, IR, 1H NMR and mass spectral studies. Some of the newly synthesized compounds were tested for analgesic activity and compounds 5b, 5c, and 5d exhibited promising analgesic activity.

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Year:  1999        PMID： 10384714     DOI： 10.1016/s0014-827x(99)00016-6

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  20 in total

1.  Experimental and DFT computational studies on 5-benzyl-4-(3,4-dimethoxyphenethyl)-2H-1,2,4-triazol-3(4H)-one.

Authors:  Hasan Tanak; Yavuz Köysal; Metin Yavuz; Orhan Büyükgüngör; Kemal Sancak
Journal:  J Mol Model       Date:  2009-07-22       Impact factor: 1.810

2.  4-(3-Methoxy-phen-yl)-3-[2-(4-methoxy-phen-yl)eth-yl]-1H-1,2,4-triazol-5(4H)-one.

Authors:  Muhammad Hanif; Ghulam Qadeer; Nasim Hasan Rama; Javeed Akhtar; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-28

3.  5-(3-Methoxy-pheneth-yl)-4-(2-methoxy-phen-yl)-4H-1,2,4-triazol-3-ol.

Authors:  Muhammad Hanif; Ghulam Qadeer; Nasim Hasan Rama; Wai-Yeung Wong
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-25

4.  N-[(4-Amino-5-sulfanyl-idene-4,5-dihydro-1H-1,2,4-triazol-3-yl)meth-yl]-4-methyl-benzamide.

Authors:  Hoong-Kun Fun; Chin Sing Yeap; Yatin Mange; Arun M Isloor; Chitrakar Hegde
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-04

5.  4-(4-Methoxy-phen-yl)-3-[2-(2-methoxy-phen-yl)eth-yl]-1H-1,2,4-triazol-5(4H)-one.

Authors:  Muhammad Hanif; Ghulam Qadeer; Nasim Hasan Rama; Javeed Akhtar; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-31

6.  5-(2-Methoxy-benz-yl)-4-(2-methoxy-phen-yl)-4H-1,2,4-triazol-3-ol.

Authors:  Muhammad Hanif; Ghulam Qadeer; Nasim Hasan Rama; Javeed Akhtar; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-01-17

7.  4-(2-Methoxy-phenyl)-3-(3,4,5-tri-methoxy-phen-ethyl)-2H-1,2,4-triazole-5(4H)-thione.

Authors:  Ghulam Qadeer; Nasim Hasan Rama; Javeed Akhtar; Mohammad Azad Malik; Madeleine Helliwell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2007-12-18

8.  3-(3-Methoxy-benz-yl)-4-(2-methoxy-phen-yl)-1H-1,2,4-triazole-5(4H)-thione.

Authors:  Muhammad Hanif; Ghulam Qadeer; Nasim Hasan Rama; Ales Ruzicka
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-11-13

9.  4-[4-(Diethyl-amino)benzyl-ideneamino]-4H-1,2,4-triazole.

Authors:  Jian Xin Pan; Ju Zhou Zhang; Qian Wang Chen
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-05-03

10.  Synthesis and antimicrobial evaluation of some novel 1,2,4-triazole and 1,3,4-thiadiazole derivatives.

Authors:  Lukasz Popiołek; Urszula Kosikowska; Liliana Mazur; Maria Dobosz; Anna Malm
Journal:  Med Chem Res       Date:  2012-11-11       Impact factor: 1.965
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