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Literature DB >> 2536847

Identification of a transforming gene of human papillomavirus type 16.

A Tanaka¹, T Noda, H Yajima, M Hatanaka, Y Ito.

Abstract

Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation.

Entities: Species

Mesh：

Substances：
Growth Substances
DNA

Year: 1989 PMID： 2536847 PMCID： PMC247853

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

30 in total

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Authors: L Gissmann; V Diehl; H J Schultz-Coulon; H zur Hausen
Journal: J Virol Date: 1982-10 Impact factor: 5.103

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Authors: K Seedorf; G Krämmer; M Dürst; S Suhai; W G Röwekamp
Journal: Virology Date: 1985-08 Impact factor: 3.616

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Authors: H Okayama; P Berg
Journal: Mol Cell Biol Date: 1983-02 Impact factor: 4.272

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Authors: M Dürst; L Gissmann; H Ikenberg; H zur Hausen
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

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Authors: G Matlashewski; J Schneider; L Banks; N Jones; A Murray; L Crawford
Journal: EMBO J Date: 1987-06 Impact factor: 11.598

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Authors: M Boshart; L Gissmann; H Ikenberg; A Kleinheinz; W Scheurlen; H zur Hausen
Journal: EMBO J Date: 1984-05 Impact factor: 11.598

31 in total

1. Intranuclear localization of human papillomavirus 16 E7 during transformation and preferential binding of E7 to the Rb family member p130.

Authors: K Smith-McCune; D Kalman; C Robbins; S Shivakumar; L Yuschenkoff; J M Bishop
Journal: Proc Natl Acad Sci U S A Date: 1999-06-08 Impact factor: 11.205

2. Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.

Authors: G A Gulliver; R L Herber; A Liem; P F Lambert
Journal: J Virol Date: 1997-08 Impact factor: 5.103

3. Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

Authors: W C Phelps; K Münger; C L Yee; J A Barnes; P M Howley
Journal: J Virol Date: 1992-04 Impact factor: 5.103

4. Induction of the HPV16 enhancer activity by Jun-B and c-Fos through cooperation of the promoter-proximal AP-1 site and the epithelial cell type--specific regulatory element in fibroblasts.

Authors: K Kikuchi; A Taniguchi; S Yasumoto
Journal: Virus Genes Date: 1996 Impact factor: 2.332

5. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

Authors: M Scheffner; K Münger; J C Byrne; P M Howley
Journal: Proc Natl Acad Sci U S A Date: 1991-07-01 Impact factor: 11.205

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Authors: K Münger; C L Yee; W C Phelps; J A Pietenpol; H L Moses; P M Howley
Journal: J Virol Date: 1991-07 Impact factor: 5.103

7. Use of a rapid, efficient inoculation method to induce papillomas by cottontail rabbit papillomavirus DNA shows that the E7 gene is required.

Authors: J L Brandsma; Z H Yang; S W Barthold; E A Johnson
Journal: Proc Natl Acad Sci U S A Date: 1991-06-01 Impact factor: 11.205