Literature DB >> 10358058

Molecular characterization of cytosolic phospholipase A2-beta.

C Song1, X J Chang, K M Bean, M S Proia, J L Knopf, R W Kriz.   

Abstract

We have isolated a cDNA encoding a 1012-amino acid polypeptide cPLA2-beta, that has significant homology with cPLA2-alpha in both the calcium-dependent lipid binding domain as well as in the catalytic domain. Transient expression of cPLA2-beta cDNA in COS cells results in an increase in calcium-dependent phospholipase A1 (PLA1) and PLA2 activities compared with vector-transfected cells. cPLA2-beta is markedly less selective for cleavage at sn-2 as compared with cPLA2-alpha and cPLA2-gamma. Northern analysis reveals a cPLA2-beta transcript of 8 kilobase pairs that is expressed in all the human tissues examined. With the identification of cPLA2-beta, the newly defined cPLA2 family now comprises three members that may have dramatically different mechanisms for regulation of expression and enzymatic activation.

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Year:  1999        PMID： 10358058     DOI： 10.1074/jbc.274.24.17063

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  29 in total

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Authors:  Haowei Song; Sasanka Ramanadham; Shunzhong Bao; Fong-Fu Hsu; John Turk
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Review 2.  The metabolic serine hydrolases and their functions in mammalian physiology and disease.

Authors:  Jonathan Z Long; Benjamin F Cravatt
Journal:  Chem Rev       Date:  2011-06-23       Impact factor: 60.622

Review 3.  Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

Authors:  Edward A Dennis; Jian Cao; Yuan-Hao Hsu; Victoria Magrioti; George Kokotos
Journal:  Chem Rev       Date:  2011-09-12       Impact factor: 60.622

4.  Insulin secretory responses and phospholipid composition of pancreatic islets from mice that do not express Group VIA phospholipase A2 and effects of metabolic stress on glucose homeostasis.

Authors:  Shunzhong Bao; Haowei Song; Mary Wohltmann; Sasanka Ramanadham; Wu Jin; Alan Bohrer; John Turk
Journal:  J Biol Chem       Date:  2006-05-27       Impact factor: 5.157

Review 5.  Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.

Authors:  Kanchan Sonkar; Vinay Ayyappan; Caitlin M Tressler; Oluwatobi Adelaja; Ruoqing Cai; Menglin Cheng; Kristine Glunde
Journal:  NMR Biomed       Date:  2019-06-11       Impact factor: 4.044

6.  Effects of stable suppression of Group VIA phospholipase A2 expression on phospholipid content and composition, insulin secretion, and proliferation of INS-1 insulinoma cells.

Authors:  Shunzhong Bao; Alan Bohrer; Sasanka Ramanadham; Wu Jin; Sheng Zhang; John Turk
Journal:  J Biol Chem       Date:  2005-11-14       Impact factor: 5.157

7.  Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+.

Authors:  Mikhail Strokin; Marina Sergeeva; Georg Reiser
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739

8.  Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells.

Authors:  Dawn E Tucker; Allison Stewart; Laxman Nallan; Pravine Bendale; Farideh Ghomashchi; Michael H Gelb; Christina C Leslie
Journal:  J Lipid Res       Date:  2005-08-01       Impact factor: 5.922

9.  Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death.

Authors:  Ava L Taylor; Joseph V Bonventre; Tracy F Uliasz; James A Hewett; Sandra J Hewett
Journal:  J Neurochem       Date:  2008-06-28       Impact factor: 5.372

Review 10.  Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.

Authors:  Evelin L Schaeffer; Orestes V Forlenza; Wagner F Gattaz
Journal:  Psychopharmacology (Berl)       Date:  2008-10-14       Impact factor: 4.530
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