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Literature DB >> 31184789

Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.

Kanchan Sonkar¹, Vinay Ayyappan¹, Caitlin M Tressler¹, Oluwatobi Adelaja¹, Ruoqing Cai¹, Menglin Cheng¹, Kristine Glunde^1,2.

Abstract

Activated choline metabolism is a hallmark of carcinogenesis and tumor progression, which leads to elevated levels of phosphocholine and glycerophosphocholine in all types of cancer tested so far. Magnetic resonance spectroscopy applications have played a key role in detecting these elevated choline phospholipid metabolites. To date, the majority of cancer-related studies have focused on phosphocholine and the Kennedy pathway, which constitutes the biosynthesis pathway for membrane phosphatidylcholine. Fewer and more recent studies have reported on the importance of glycerophosphocholine in cancer. In this review article, we summarize the recent literature on glycerophosphocholine metabolism with respect to its cancer biology and its detection by magnetic resonance spectroscopy applications.

Entities: CellLine Chemical Disease Gene Species

Keywords: MR spectroscopy (MRS) and spectroscopic imaging (MRSI) methods; applications: cellular and molecular cancer imaging; applications: metastases; cancer; cancer therapy responses; cancer: applications; methods and engineering: cancer

Mesh：

Substances：

Year: 2019 PMID： 31184789 PMCID： PMC6803034 DOI： 10.1002/nbm.4112

Source DB: PubMed Journal: NMR Biomed ISSN： 0952-3480 Impact factor: 4.044

324 in total

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4. Highlight report: Role of choline phospholipid metabolism in tumor progression.

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5. Hepatopancreatic metabolomics shedding light on the mechanism underlying unsynchronized growth in giant freshwater prawn, Macrobrachium rosenbergii.

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