Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice.

Literature DB >> 10225929

The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice.

B H Bellaire¹, P H Elzer, C L Baldwin, R M Roop.

Abstract

2,3-Dihydroxybenzoic acid (DHBA) is the only siderophore described for Brucella, and previous studies suggested that DHBA might contribute to the capacity of these organisms to persist in host macrophages. Employing an isogenic siderophore mutant (DeltaentC) constructed from virulent Brucella abortus 2308, however, we found that production of DHBA is not required for replication in cultured murine macrophages or for the establishment and maintenance of chronic infection in the BALB/c mouse model.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1999 PMID： 10225929 PMCID： PMC116012

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

Review 1. Cellular iron metabolism in health and disease.

Authors: E D Weinberg
Journal: Drug Metab Rev Date: 1990 Impact factor: 4.518

2. Novel iron uptake system specified by ColV plasmids: an important component in the virulence of invasive strains of Escherichia coli.

Authors: P H Williams
Journal: Infect Immun Date: 1979-12 Impact factor: 3.441

3. Universal chemical assay for the detection and determination of siderophores.

Authors: B Schwyn; J B Neilands
Journal: Anal Biochem Date: 1987-01 Impact factor: 3.365

4. Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (EntB) is a bifunctional enzyme that is phosphopantetheinylated by EntD and then acylated by EntE using ATP and 2,3-dihydroxybenzoate.

Authors: A M Gehring; K A Bradley; C T Walsh
Journal: Biochemistry Date: 1997-07-15 Impact factor: 3.162

5. DNA sequencing with chain-terminating inhibitors.

Authors: F Sanger; S Nicklen; A R Coulson
Journal: Proc Natl Acad Sci U S A Date: 1977-12 Impact factor: 11.205

6. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron.

Authors: T F Byrd; M A Horwitz
Journal: J Clin Invest Date: 1989-05 Impact factor: 14.808

7. Studies on transformation of Escherichia coli with plasmids.

Authors: D Hanahan
Journal: J Mol Biol Date: 1983-06-05 Impact factor: 5.469

8. TnphoA: a transposon probe for protein export signals.

Authors: C Manoil; J Beckwith
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205

9. Nucleotide sequence and transcriptional organization of the Escherichia coli enterobactin biosynthesis cistrons entB and entA.

Authors: M S Nahlik; T J Brickman; B A Ozenberger; M A McIntosh
Journal: J Bacteriol Date: 1989-02 Impact factor: 3.490

10. Cloning, mutagenesis, and nucleotide sequence of a siderophore biosynthetic gene (amoA) from Aeromonas hydrophila.

Authors: S Barghouthi; S M Payne; J E Arceneaux; B R Byers
Journal: J Bacteriol Date: 1991-08 Impact factor: 3.490

18 in total

1. Brucella melitensis: a nasty bug with hidden credentials for virulence.

Authors: Edgardo Moreno; Ignacio Moriyon
Journal: Proc Natl Acad Sci U S A Date: 2002-01-08 Impact factor: 11.205

2. Characterization of Mutations That Affect the Nonoxidative Pentose Phosphate Pathway in Sinorhizobium meliloti.

Authors: Justin P Hawkins; Patricia A Ordonez; Ivan J Oresnik
Journal: J Bacteriol Date: 2017-12-20 Impact factor: 3.490

3. Iron homeostasis in Brucella abortus: the role of bacterioferritin.

Authors: Marta A Almirón; Rodolfo A Ugalde
Journal: J Microbiol Date: 2010-11-03 Impact factor: 3.422

4. The genome sequence of the facultative intracellular pathogen Brucella melitensis.

Authors: Vito G DelVecchio; Vinayak Kapatral; Rajendra J Redkar; Guy Patra; Cesar Mujer; Tamara Los; Natalia Ivanova; Iain Anderson; Anamitra Bhattacharyya; Athanasios Lykidis; Gary Reznik; Lynn Jablonski; Niels Larsen; Mark D'Souza; Axel Bernal; Mikhail Mazur; Eugene Goltsman; Eugene Selkov; Philip H Elzer; Sue Hagius; David O'Callaghan; Jean-Jacques Letesson; Robert Haselkorn; Nikos Kyrpides; Ross Overbeek
Journal: Proc Natl Acad Sci U S A Date: 2001-12-26 Impact factor: 11.205

5. Identification of genes required for chronic persistence of Brucella abortus in mice.

Authors: P C Hong; R M Tsolis; T A Ficht
Journal: Infect Immun Date: 2000-07 Impact factor: 3.441

6. Comparative phylogenomics and evolution of the Brucellae reveal a path to virulence.

Authors: Alice R Wattam; Jeffrey T Foster; Shrinivasrao P Mane; Stephen M Beckstrom-Sternberg; James M Beckstrom-Sternberg; Allan W Dickerman; Paul Keim; Talima Pearson; Maulik Shukla; Doyle V Ward; Kelly P Williams; Bruno W Sobral; Renee M Tsolis; Adrian M Whatmore; David O'Callaghan
Journal: J Bacteriol Date: 2013-12-13 Impact factor: 3.490

7. Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low-iron conditions in vitro.

Authors: Bryan H Bellaire; Philip H Elzer; Cynthia L Baldwin; R Martin Roop
Journal: Infect Immun Date: 2003-05 Impact factor: 3.441

8. The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M.

Authors: Isabelle Danese; Valerie Haine; Rose-May Delrue; Anne Tibor; Pascal Lestrate; Olivier Stevaux; Pascal Mertens; Jean-Yves Paquet; Jacques Godfroid; Xavier De Bolle; Jean-Jacques Letesson
Journal: Infect Immun Date: 2004-10 Impact factor: 3.441

Review 9. Survival of the fittest: how Brucella strains adapt to their intracellular niche in the host.

Authors: R Martin Roop; Jennifer M Gaines; Eric S Anderson; Clayton C Caswell; Daniel W Martin
Journal: Med Microbiol Immunol Date: 2009-09-22 Impact factor: 3.402

10. The AraC-like transcriptional regulator DhbR is required for maximum expression of the 2,3-dihydroxybenzoic acid biosynthesis genes in Brucella abortus 2308 in response to iron deprivation.

Authors: Eric S Anderson; James T Paulley; R Martin Roop
Journal: J Bacteriol Date: 2007-12-21 Impact factor: 3.490