Literature DB >> 10203545

High prevalence of GB virus C in Brazil and molecular evidence for intrafamilial transmission.

J R Pinho1, P M Zanotto, J L Ferreira, L M Sumita, F J Carrilho, L C da Silva, M L Capacci, A O Silva, B Guz, F L Gonçales, N S Gonçales, G A Buck, G A Meyers, A P Bernardini.   

Abstract

The prevalence of GB virus C (GBV-C) in candidate Brazilian blood donors with normal and elevated alanine aminotransferase levels was found to be 5.2% (5 of 95) and 6.5% (5 of 76), respectively. Among Brazilian patients, GBV-C was found in 9.5% (13 of 137) of cases of hepatitis not caused by hepatitis A virus (HAV), HBV, HCV, HDV, or HEV (non-A-E hepatitis) and in 18.2% (8 of 44) of individuals infected with HCV. Molecular characterization of GBV-C by partial sequencing of the NS3 region showed clustering between members of a single family, implying intrafamilial transmission. In conclusion, these results together suggest that contagion mechanisms which facilitate intrafamilial transmission of GBV-C may partially explain the high prevalence of viremic carriers worldwide.

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Year:  1999        PMID： 10203545      PMCID： PMC84861     

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  22 in total

1.  Consensus oligonucleotide primers for the detection of GB virus C in human cryptogenic hepatitis.

Authors:  T P Leary; A S Muerhoff; J N Simons; T J Pilot-Matias; J C Erker; M L Chalmers; G G Schlauder; G J Dawson; S M Desai; I K Mushahwar
Journal:  J Virol Methods       Date:  1996-01       Impact factor: 2.014

2.  High prevalence of GB virus C infection in a group of Italian patients with hepatitis of unknown etiology.

Authors:  G Fiordalisi; I Zanella; G Mantero; A Bettinardi; R Stellini; G Paraninfo; G Cadeo; D Primi
Journal:  J Infect Dis       Date:  1996-07       Impact factor: 5.226

3.  Avoiding false positives with PCR.

Authors:  S Kwok; R Higuchi
Journal:  Nature       Date:  1989-05-18       Impact factor: 49.962

4.  Prevalence studies of GB virus-C infection using reverse transcriptase-polymerase chain reaction.

Authors:  G J Dawson; G G Schlauder; T J Pilot-Matias; D Thiele; T P Leary; P Murphy; J E Rosenblatt; J N Simons; F E Martinson; R A Gutierrez; J R Lentino; C Pachucki; A S Muerhoff; A Widell; G Tegtmeier; S Desai; I K Mushahwar
Journal:  J Med Virol       Date:  1996-09       Impact factor: 2.327

5.  Vertical transmission of hepatitis G.

Authors:  H H Feucht; B Zollner; S Polywka; R Laufs
Journal:  Lancet       Date:  1996-03-02       Impact factor: 79.321

6.  Interspousal transmission of GB virus-C/hepatitis G virus: a comparison with hepatitis C virus.

Authors:  J H Kao; C J Liu; P J Chen; W Chen; S C Hsiang; M Y Lai; D S Chen
Journal:  J Med Virol       Date:  1997-12       Impact factor: 2.327

7.  Identification of conserved nucleotide sequences within the GB virus C 5'-untranslated region: design of PCR primers for detection of viral RNA.

Authors:  A S Muerhoff; J N Simons; J C Erker; S M Desai; I K Mushahwar
Journal:  J Virol Methods       Date:  1996-10       Impact factor: 2.014

8.  Detection of hepatitis G virus RNA in patients with hepatitis B, hepatitis C, and non-A-E hepatitis by RT-PCR using multiple primer sets.

Authors:  X H Zhang; H Shinzawa; L Shao; M Ishibashi; K Saito; S Ohno; N Yamada; H Misawa; H Togashi; T Takahashi
Journal:  J Med Virol       Date:  1997-08       Impact factor: 2.327

9.  Isolation of novel virus-like sequences associated with human hepatitis.

Authors:  J N Simons; T P Leary; G J Dawson; T J Pilot-Matias; A S Muerhoff; G G Schlauder; S M Desai; I K Mushahwar
Journal:  Nat Med       Date:  1995-06       Impact factor: 53.440

10.  Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent.

Authors:  J Linnen; J Wages; Z Y Zhang-Keck; K E Fry; K Z Krawczynski; H Alter; E Koonin; M Gallagher; M Alter; S Hadziyannis; P Karayiannis; K Fung; Y Nakatsuji; J W Shih; L Young; M Piatak; C Hoover; J Fernandez; S Chen; J C Zou; T Morris; K C Hyams; S Ismay; J D Lifson; G Hess; S K Foung; H Thomas; D Bradley; H Margolis; J P Kim
Journal:  Science       Date:  1996-01-26       Impact factor: 47.728
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  3 in total

Review 1.  What do we need to know about non-A-to-E viral hepatitis?

Authors:  K V Menon; N N Zein
Journal:  Curr Gastroenterol Rep       Date:  2000-02

2.  Prevalence, incidence density, and genotype distribution of GB virus C infection in a cohort of recently HIV-1-infected subjects in Sao Paulo, Brazil.

Authors:  Maria Teresa M Giret; João Luiz Miraglia; Maria Cecília Araripe Sucupira; Anna Nishiya; José Eduardo Levi; Ricardo S Diaz; Ester C Sabino; Esper G Kallas
Journal:  PLoS One       Date:  2011-04-05       Impact factor: 3.240

3.  Frequency and genotypic distribution of GB virus C (GBV-C) among Colombian population with Hepatitis B (HBV) or Hepatitis C (HCV) infection.

Authors:  Mónica V Alvarado-Mora; Livia Botelho; Anna Nishiya; Raymundo A Neto; Michele S Gomes-Gouvêa; Maria F Gutierrez; Flair J Carrilho; João Rr Pinho
Journal:  Virol J       Date:  2011-07-11       Impact factor: 4.099
  3 in total

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