| Literature DB >> 8560265 |
J Linnen1, J Wages, Z Y Zhang-Keck, K E Fry, K Z Krawczynski, H Alter, E Koonin, M Gallagher, M Alter, S Hadziyannis, P Karayiannis, K Fung, Y Nakatsuji, J W Shih, L Young, M Piatak, C Hoover, J Fernandez, S Chen, J C Zou, T Morris, K C Hyams, S Ismay, J D Lifson, G Hess, S K Foung, H Thomas, D Bradley, H Margolis, J P Kim.
Abstract
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.Entities:
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Year: 1996 PMID： 8560265 DOI： 10.1126/science.271.5248.505
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728